日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 科研級生物類似抗體
  4. CSF2RB (Trabikibart Biosimilar) Recombinant Monoclonal Antibody

CSF2RB (Trabikibart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA006047MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSF2RB（Trabikibart Biosimilar Antibody）重組單克隆抗體是一種針對人類CSF2RB蛋白，其靶標(biāo)分子具有豐富的別名，包括Beta-C、CD131、CDw131、集落刺激因子2受體β鏈、細(xì)胞因子受體共同β亞基等，是粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF）、白細(xì)胞介素3（IL-3）和白細(xì)胞介素5（IL-5）受體的共同β亞基，在細(xì)胞因子信號傳導(dǎo)中發(fā)揮關(guān)鍵作用。該抗體以重組人CSF2RB蛋白制備，具有高度的種屬特異性，僅對人類來源的靶標(biāo)分子產(chǎn)生反應(yīng)。 Trabikibart Biosimilar Antibody作為靶向CSF2RB抗體，Trabikibart類似物，可通過阻斷GM-CSF/IL-3/IL-5介導(dǎo)的信號通路，抑制炎癥細(xì)胞的活化與增殖，為哮喘、特發(fā)性肺纖維化、類風(fēng)濕關(guān)節(jié)炎等疾病提供潛在治療方案。目前，相關(guān)藥物的臨床試驗(yàn)正探索其在炎癥性腸病、慢性阻塞性肺疾病等適應(yīng)癥中的療效與安全性，旨在通過精準(zhǔn)靶向免疫調(diào)節(jié)改善患者預(yù)后。 該抗體是研究細(xì)胞因子受體信號網(wǎng)絡(luò)的重要工具。由于其嚴(yán)格的人類種屬反應(yīng)性，適用于人源細(xì)胞系、原代細(xì)胞及組織樣本的實(shí)驗(yàn)研究，可用于檢測細(xì)胞表面CSF2RB的表達(dá)水平、免疫沉淀分析受體復(fù)合物的相互作用、染色觀察受體的亞細(xì)胞定位等。此外，通過中和CSF2RB活性，研究者可深入探究其在造血干細(xì)胞分化、炎癥反應(yīng)調(diào)控、免疫細(xì)胞功能維持等生理病理過程中的機(jī)制，為開發(fā)新型靶向藥物提供理論依據(jù)。其其特性也為抗體類似物的一致性評價、生產(chǎn)工藝優(yōu)化及成本控制研究提供了參考模型。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Beta-C; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity；granulocyte macrophage; Common beta chain; Csf2rb; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor；CDw131 antigen; Cytokine receptor common subunit beta; GM CSF/IL 3/IL 5 receptor common beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; granulocyte-macrophage colony-stimulating factor receptor, beta; IL3RB; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor, beta; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta；high affinity; Interleukin 5 receptor, beta; SMDP5; stimulating factor 3 receptor, beta；high affinity
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CSF2RB protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
  • 基因功能參考文獻(xiàn)：
    1. SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis. PMID: 28131718
    2. Exome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals. PMID: 27373512
    3. In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease. PMID: 27377463
    4. VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
    5. These data suggest that expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis PMID: 23108143
    6. JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling. PMID: 21965659
    7. Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells. PMID: 21176354
    8. Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils PMID: 20705940
    9. The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population. PMID: 21247258
    10. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report] PMID: 21205713
    11. the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation. PMID: 21207215
    12. The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration. PMID: 20802515
    13. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling PMID: 20516062
    14. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms. PMID: 20472554
    15. hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex. PMID: 12384414
    16. JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR PMID: 12488507
    17. Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains PMID: 15060062
    18. A minor improvement in resolution has given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule. PMID: 16754968
    19. These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. PMID: 16767694
    20. This study found that several markers (rs2072707, rs2284031 and rs909486)of csf2rb showed sex-specific and family history-dependent associations with schizophrenia. PMID: 17667962
    21. The dynamic role of the common signaling subunit beta c is to prevent IL5alpha and GM-CSF ligand-receptor complexes from rapidly dissociating. PMID: 18294864
    22. The interaction between intercellular adhesion molecule 1 (ICAM-1) and the GM-CSF receptor is essential for GM-CSF-induced eosinophil activation and survival. PMID: 18322230
    23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
    24. Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit. PMID: 18374598

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Pulmonary surfactant metabolism dysfunction 5 (SMDP5)
  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 4 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2436

    OMIM: 138981

    KEGG: hsa:1439

    STRING: 9606.ENSP00000384053

    UniGene: Hs.592192



×
生命科學(xué)計算平臺