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  4. CSF1 (Lacnotuzumab Biosimilar) Recombinant Monoclonal Antibody

CSF1 (Lacnotuzumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA006043MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSF1 (Lacnotuzumab Biosimilar Antibody) 重組單克隆抗體是一種靶向集落刺激因子1（CSF1），其別名為CP25抗體、HHO.C8抗體、Homeo box 3C抗體、Homeo box C6抗體、Homeo box C8蛋白抗體、Homeobox C6抗體、Homeobox蛋白CP25抗體、Homeobox蛋白HHO.C8抗體、Homeobox蛋白Hox-3C抗體、Homeobox蛋白Hox-C6抗體、HOX3抗體、HOX3C抗體、Hoxc6抗體、HXC6_HUMAN抗體等。該抗體以重組人CSF1蛋白制備而成，具有高度的種屬反應(yīng)性，主要針對人類CSF1分子發(fā)揮特異性結(jié)合作用。 Lacnotuzumab作為CSF1抑制劑藥物，在臨床應(yīng)用中旨在探索對CSF1信號通路異常相關(guān)疾病的治療潛力，例如類風(fēng)濕關(guān)節(jié)炎、特發(fā)性肺纖維化等慢性炎癥性疾病，以及部分實體瘤（如胰腺癌、乳腺癌）的免疫治療，通過阻斷CSF1/CSF1R軸減少腫瘤相關(guān)巨噬細(xì)胞浸潤，改善腫瘤微環(huán)境，增強抗腫瘤免疫應(yīng)答。 該重組單克隆抗體為研究CSF1的生物學(xué)功能提供了重要工具。研究者可利用其特異性結(jié)合能力，在細(xì)胞實驗中檢測CSF1的表達(dá)水平、定位及相互作用蛋白，或在動物模型中通過中和內(nèi)源性CSF1，觀察其對巨噬細(xì)胞功能、炎癥反應(yīng)及疾病進(jìn)展的影響，深入探討CSF1在免疫調(diào)節(jié)、組織穩(wěn)態(tài)及疾病發(fā)生發(fā)展中的分子機制，為相關(guān)疾病的靶點驗證和新藥研發(fā)奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein Hox-3C antibody; Homeobox protein Hox-C6 antibody; HOX3 antibody; HOX3C antibody; Hoxc6 antibody; HXC6_HUMAN antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CSF1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻(xiàn)：
    1. our findings indicate that HOXC6 plays an important role in the progress and prognosis of human glioma and promotes glioma U87 cell growth through the WIF-1/Wnt signaling pathway PMID: 30228024
    2. Overall, the data show that miR-185 could negatively target HOXC6 to suppress cell proliferation, promotes apoptosis and autophagy through inhibiting TGF-beta1/mTOR axis in nasopharyngeal carcinoma (NPC). Thus, miR-185 is useful strategy for the treatment of NPC. PMID: 29991129
    3. HOXC6 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
    4. HOXC6 thus appears to promote colorectal cancer cell proliferation and tumorigenesis through autophagy inhibition PMID: 27081081
    5. Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9. The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells. PMID: 27573865
    6. oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner PMID: 27574949
    7. HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation. PMID: 26310814
    8. Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors. PMID: 26046583
    9. Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo. PMID: 25725483
    10. HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID: 24525058
    11. HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1 PMID: 22907429
    12. Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations. PMID: 23581417
    13. HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression. PMID: 22896703
    14. These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner. PMID: 21683083
    15. proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3) PMID: 15637592
    16. HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. PMID: 17488478

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5128

    OMIM: 142972

    KEGG: hsa:3223

    STRING: 9606.ENSP00000243108

    UniGene: Hs.549040



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