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  4. CLEC9A (US20230374142A1 Biosimilar) Recombinant Monoclonal Antibody

CLEC9A (US20230374142A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA740922MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLEC9A重組單克隆抗體（US20230374142A1 Biosimilar Antibody）是一種針對(duì)C型凝集素結(jié)構(gòu)域家族9成員A（CLEC9A）的生物治療藥物，其別名為C-type lectin domain family 9 member A抗體、CLC9A_HUMAN抗體、DNGR1抗體、HEEE9341抗體、PRO34046抗體或UNQ9341抗體。該抗體以重組人CLEC9A蛋白制備，具有高度的人源種屬反應(yīng)性，專門(mén)靶向人類(lèi)CLEC9A分子。 CLEC9A作為樹(shù)突狀細(xì)胞（DC）表面的關(guān)鍵受體，在抗原呈遞和免疫激活中發(fā)揮重要作用。針對(duì)該靶點(diǎn)類(lèi)似物被廣泛探索用于癌癥免疫治療，通過(guò)調(diào)節(jié)DC功能增強(qiáng)T細(xì)胞抗腫瘤免疫應(yīng)答。目前，相關(guān)藥物研究聚焦于其在實(shí)體瘤和血液系統(tǒng)惡性腫瘤中的應(yīng)用，包括單藥治療或與免疫檢查點(diǎn)抑制劑、化療等聯(lián)合方案的協(xié)同效應(yīng)，旨在提高腫瘤微環(huán)境的免疫原性，改善患者預(yù)后。此外，CLEC9A相關(guān)藥物在自身免疫性疾病和感染性疾病的免疫調(diào)節(jié)研究中也展現(xiàn)出潛在價(jià)值。 CLEC9A抗體是解析天然免疫與適應(yīng)性免疫調(diào)控機(jī)制的重要工具。研究者可利用該抗體進(jìn)行CLEC9A蛋白的表達(dá)檢測(cè)、細(xì)胞定位分析及功能阻斷實(shí)驗(yàn)，深入探究其在DC分化成熟、抗原交叉呈遞以及免疫耐受維持中的分子機(jī)制。同時(shí)，基于其高度特異性，該抗體助力CLEC9A相關(guān)信號(hào)通路及疾病模型的研究，為開(kāi)發(fā)新型免疫治療策略提供理論依據(jù)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C type lectin domain family 9; member A antibody; C-type lectin domain family 9 member A antibody; CLC9A_HUMAN antibody; CLEC9A antibody; DNGR1 antibody; HEEE9341 antibody; PRO34046 antibody; UNQ9341 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC9A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy PMID: 27250027
    2. findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection PMID: 29065139
    3. Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity. PMID: 24910448
    4. Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease. PMID: 24049150
    5. study showsn that the DNGR-1 ligand is preserved from yeast to man and corresponds to the F-actin component of the cellular cytoskeleton; identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity PMID: 22483800
    6. High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans. PMID: 22442345
    7. propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines. PMID: 22483802
    8. Data show that CLEC9A is only expressed on immature BDCA3(+) myeloid dendritic cells (mDCs). PMID: 22234694
    9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
    10. A population of human dendritic cells (DC) that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function, is characterized. PMID: 20479117
    11. DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin of the NK cell receptor group PMID: 18497879
    12. CLEC9A functions as an activation receptor PMID: 18408006
    13. analysis of differences between mouse and human Clec9A PMID: 18669894
    14. CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens PMID: 19219027
    15. The paper cited (J Clin Invest. 2008 Jun;118(6):2098-110) is the first characterization of human and mouse CLEC9A (a.k.a DNGR-1) PMID: 18497879

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 組織特異性：
    In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26705

    OMIM: 612252

    KEGG: hsa:283420

    STRING: 9606.ENSP00000348074

    UniGene: Hs.531189



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