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  4. CLEC4C (SSGJ-626 Biosimilar) Recombinant Monoclonal Antibody

CLEC4C (SSGJ-626 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA855470MB4HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLEC4C(SSGJ-626 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途設(shè)計(jì)的生物試劑，可特異性識(shí)別并結(jié)合C型凝集素家族成員CLEC4C（C-type lectin domain family 4 member C）蛋白。該抗體通過基因工程技術(shù)重組表達(dá)，具有高度的抗原結(jié)合特異性和批次間一致性，為免疫學(xué)、細(xì)胞生物學(xué)及相關(guān)領(lǐng)域的基礎(chǔ)研究提供可靠工具。 CLEC4C作為重要的免疫調(diào)節(jié)分子，主要表達(dá)于樹突狀細(xì)胞、巨噬細(xì)胞等抗原呈遞細(xì)胞表面，在天然免疫識(shí)別、炎癥反應(yīng)調(diào)控及病原體清除過程中發(fā)揮關(guān)鍵作用。本產(chǎn)品可用于等多種實(shí)驗(yàn)技術(shù)，助力研究CLEC4C在免疫信號(hào)通路中的功能機(jī)制，以及其與疾病發(fā)生發(fā)展的關(guān)聯(lián)。 該抗體經(jīng)過嚴(yán)格的質(zhì)量控制，包括效價(jià)測(cè)定、純度分析及交叉反應(yīng)性檢測(cè)，確保在科研實(shí)驗(yàn)中展現(xiàn)穩(wěn)定的性能。其重組表達(dá)體系有效避免了傳統(tǒng)抗體制備過程中的批次差異問題，可滿足長(zhǎng)期實(shí)驗(yàn)的重復(fù)性需求。適用于細(xì)胞系、原代細(xì)胞及組織樣本中CLEC4C蛋白的定性與定量分析，為探索天然免疫調(diào)控網(wǎng)絡(luò)、開發(fā)新型免疫治療策略等研究方向提供有力支持。 本產(chǎn)品僅限于實(shí)驗(yàn)室研究使用，不可用于診斷或治療用途。建議在-20℃條件下儲(chǔ)存，避免反復(fù)凍融以保證抗體活性。通過特異性靶向CLEC4C分子，該試劑為深入解析免疫調(diào)節(jié)機(jī)制及相關(guān)疾病的分子基礎(chǔ)提供了重要實(shí)驗(yàn)手段。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BDCA2 research-grade biosimilar; SSGJ-626 research-grade biosimilar; 626 research-grade biosimilar ;CLEC4C antibody; BDCA2 antibody; CLECSF11 antibody; CLECSF7 antibody; DLEC antibody; HECL antibody; UNQ9361/PRO34150 antibody; C-type lectin domain family 4 member C antibody; Blood dendritic cell antigen 2 antibody; BDCA-2 antibody; C-type lectin superfamily member 7 antibody; Dendritic lectin antibody; CD antigen CD303 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC4C protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
  • 基因功能參考文獻(xiàn)：
    1. Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. PMID: 29796630
    2. decrease in the surface expression of CLEC4C and the endoplasmic reticulum localization of the mutant construct were observed PMID: 26943047
    3. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. PMID: 25779340
    4. BDCA-2 binds selectively to glycans containing the epitope Galbeta1-3/4GlcNAcbeta1-2Man. PMID: 25995448
    5. We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). PMID: 24425442
    6. Reduction in Treg numbers following Ag delivery to BDCA2 restored both CD4(+) T cell activation and Ab responses, demonstrating that Tregs were required for the observed tolerance. PMID: 24829416
    7. Data show that HCV envelope glycoprotein E2 is a novel ligand of blood dendritic cells antigen 2 (BDCA-2). PMID: 23053572
    8. Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. PMID: 21880719
    9. Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques. PMID: 21436634
    10. Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. PMID: 20888334
    11. Indoleamine 2,3-deoxigenase positive plasmacytoid dentritic cells are the classical BDCA2 positive cells in melanoma lymph nodes PMID: 19829303
    12. Data suggest that by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of plasmacytoid dendritic cells. PMID: 17850179
    13. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 and cytoskeletal proteins. CD303 signaling is linked with internalization by clathrin-mediated endocytosis. PMID: 18022864
    14. results suggest that downregulation of BDCA2 expression on plasmacytoid dendritic cells (pDCs) may reflect the activation of pDCs accumulated in systemic lupus erythematosus patients & may be one marker for indication of disease activity of SLE patients PMID: 18684674
    15. Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. PMID: 19577819

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13258

    OMIM: 606677

    KEGG: hsa:170482

    STRING: 9606.ENSP00000353500

    UniGene: Hs.351812



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