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  4. CLEC4C (Litifilimab Biosimilar) Recombinant Monoclonal Antibody

CLEC4C (Litifilimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA855470MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLEC4C (Litifilimab Biosimilar Antibody)重組單克隆抗體是一種針對 C 型凝集素結(jié)構(gòu)域家族 4 成員 C（CLEC4C）的特異性生物制劑，主要用于免疫學(xué)及相關(guān)疾病機(jī)制的科研探索。該抗體通過基因工程技術(shù)在重組表達(dá)系統(tǒng)中制備，具有高度的靶向性和生物活性，可特異性識別并結(jié)合 CLEC4C 分子，為研究其在免疫調(diào)節(jié)、炎癥反應(yīng)及疾病發(fā)生發(fā)展中的作用提供重要工具。 CLEC4C 作為樹突狀細(xì)胞（DC）表面的關(guān)鍵受體，在抗原提呈、免疫激活及耐受性維持中發(fā)揮重要作用。通過使用 CLEC4C 重組單克隆抗體，科研人員可深入探究 DC 細(xì)胞的功能調(diào)控機(jī)制，解析其在感染性疾病、自身免疫性疾病及腫瘤免疫中的分子通路。該抗體適用于多種實(shí)驗(yàn)場景，包括分析細(xì)胞表面標(biāo)志物表達(dá)、觀察蛋白定位、研究蛋白質(zhì)相互作用，以及體外細(xì)胞培養(yǎng)體系中調(diào)控免疫細(xì)胞功能等。 產(chǎn)品采用嚴(yán)格的質(zhì)量控制標(biāo)準(zhǔn)，確保高純度、高特異性及批次間一致性，為實(shí)驗(yàn)結(jié)果的可靠性和可重復(fù)性提供保障。作為科研用試劑，CLEC4C 重組單克隆抗體為揭示 CLEC4C 介導(dǎo)的免疫調(diào)控網(wǎng)絡(luò)、開發(fā)新型免疫治療策略提供了有力支持，尤其在免疫相關(guān)疾病的基礎(chǔ)研究領(lǐng)域具有重要應(yīng)用價(jià)值。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BIIB059 research-grade biosimilar; BIIB 059 research-grade biosimilar; BIIB-059 research-grade biosimilar ;CLEC4C antibody; BDCA2 antibody; CLECSF11 antibody; CLECSF7 antibody; DLEC antibody; HECL antibody; UNQ9361/PRO34150 antibody; C-type lectin domain family 4 member C antibody; Blood dendritic cell antigen 2 antibody; BDCA-2 antibody; C-type lectin superfamily member 7 antibody; Dendritic lectin antibody; CD antigen CD303 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC4C protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
  • 基因功能參考文獻(xiàn)：
    1. Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. PMID: 29796630
    2. decrease in the surface expression of CLEC4C and the endoplasmic reticulum localization of the mutant construct were observed PMID: 26943047
    3. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. PMID: 25779340
    4. BDCA-2 binds selectively to glycans containing the epitope Galbeta1-3/4GlcNAcbeta1-2Man. PMID: 25995448
    5. We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). PMID: 24425442
    6. Reduction in Treg numbers following Ag delivery to BDCA2 restored both CD4(+) T cell activation and Ab responses, demonstrating that Tregs were required for the observed tolerance. PMID: 24829416
    7. Data show that HCV envelope glycoprotein E2 is a novel ligand of blood dendritic cells antigen 2 (BDCA-2). PMID: 23053572
    8. Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. PMID: 21880719
    9. Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques. PMID: 21436634
    10. Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. PMID: 20888334
    11. Indoleamine 2,3-deoxigenase positive plasmacytoid dentritic cells are the classical BDCA2 positive cells in melanoma lymph nodes PMID: 19829303
    12. Data suggest that by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of plasmacytoid dendritic cells. PMID: 17850179
    13. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 and cytoskeletal proteins. CD303 signaling is linked with internalization by clathrin-mediated endocytosis. PMID: 18022864
    14. results suggest that downregulation of BDCA2 expression on plasmacytoid dendritic cells (pDCs) may reflect the activation of pDCs accumulated in systemic lupus erythematosus patients & may be one marker for indication of disease activity of SLE patients PMID: 18684674
    15. Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. PMID: 19577819

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13258

    OMIM: 606677

    KEGG: hsa:170482

    STRING: 9606.ENSP00000353500

    UniGene: Hs.351812



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