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  4. CLEC4C (BCD-256 Biosimilar) Recombinant Monoclonal Antibody

CLEC4C (BCD-256 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA855470MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLEC4C (BCD-256 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物試劑，其設(shè)計(jì)基于CLEC4C（C型凝集素結(jié)構(gòu)域家族4成員C）分子的特異性結(jié)合特性，可作為免疫學(xué)、細(xì)胞生物學(xué)及相關(guān)領(lǐng)域研究的重要工具。CLEC4C作為一種跨膜蛋白，主要表達(dá)于樹突狀細(xì)胞亞群（如漿細(xì)胞樣樹突狀細(xì)胞）表面，在天然免疫識(shí)別、病毒感染應(yīng)答及免疫調(diào)節(jié)中發(fā)揮關(guān)鍵作用。該重組單克隆抗體通過基因工程技術(shù)制備，具有高純度、高特異性和批次間一致性，能夠精準(zhǔn)識(shí)別并結(jié)合CLEC4C分子，為研究其生物學(xué)功能提供可靠手段。 在科研應(yīng)用中，CLEC4C重組單克隆抗體可用于某些實(shí)驗(yàn)，助力研究者分析CLEC4C在不同細(xì)胞群體中的表達(dá)模式，探索其在免疫信號(hào)通路中的調(diào)控機(jī)制，或深入研究相關(guān)疾病模型中CLEC4C的病理生理意義。其嚴(yán)格的生產(chǎn)工藝和質(zhì)量控制確保了實(shí)驗(yàn)結(jié)果的穩(wěn)定性與可重復(fù)性，適用于基礎(chǔ)研究及藥物靶點(diǎn)發(fā)現(xiàn)等前沿科學(xué)探索。該產(chǎn)品僅用于實(shí)驗(yàn)室研究，不用于臨床診斷或治療用途，為生命科學(xué)領(lǐng)域的科研工作者提供高質(zhì)量的分子工具支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Anti-BDCA2(Biocad) research-grade biosimilar; BCD-256 research-grade biosimilar ;CLEC4C antibody; BDCA2 antibody; CLECSF11 antibody; CLECSF7 antibody; DLEC antibody; HECL antibody; UNQ9361/PRO34150 antibody; C-type lectin domain family 4 member C antibody; Blood dendritic cell antigen 2 antibody; BDCA-2 antibody; C-type lectin superfamily member 7 antibody; Dendritic lectin antibody; CD antigen CD303 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC4C protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
  • 基因功能參考文獻(xiàn)：
    1. Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. PMID: 29796630
    2. decrease in the surface expression of CLEC4C and the endoplasmic reticulum localization of the mutant construct were observed PMID: 26943047
    3. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. PMID: 25779340
    4. BDCA-2 binds selectively to glycans containing the epitope Galbeta1-3/4GlcNAcbeta1-2Man. PMID: 25995448
    5. We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). PMID: 24425442
    6. Reduction in Treg numbers following Ag delivery to BDCA2 restored both CD4(+) T cell activation and Ab responses, demonstrating that Tregs were required for the observed tolerance. PMID: 24829416
    7. Data show that HCV envelope glycoprotein E2 is a novel ligand of blood dendritic cells antigen 2 (BDCA-2). PMID: 23053572
    8. Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. PMID: 21880719
    9. Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques. PMID: 21436634
    10. Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. PMID: 20888334
    11. Indoleamine 2,3-deoxigenase positive plasmacytoid dentritic cells are the classical BDCA2 positive cells in melanoma lymph nodes PMID: 19829303
    12. Data suggest that by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of plasmacytoid dendritic cells. PMID: 17850179
    13. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 and cytoskeletal proteins. CD303 signaling is linked with internalization by clathrin-mediated endocytosis. PMID: 18022864
    14. results suggest that downregulation of BDCA2 expression on plasmacytoid dendritic cells (pDCs) may reflect the activation of pDCs accumulated in systemic lupus erythematosus patients & may be one marker for indication of disease activity of SLE patients PMID: 18684674
    15. Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. PMID: 19577819

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13258

    OMIM: 606677

    KEGG: hsa:170482

    STRING: 9606.ENSP00000353500

    UniGene: Hs.351812



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