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  4. CLDN6 (IMAB027 Biosimilar) Recombinant Monoclonal Antibody

CLDN6 (IMAB027 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA005508MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLDN6 (IMAB027 Biosimilar Antibody) 重組單克隆抗體是一種針對Claudin-6（CLDN6）蛋白，其別名為Claudin-6抗體、CLD6_HUMAN抗體、Skullin抗體等。該抗體以重組人CLDN6蛋白制備，具有高度的種屬反應(yīng)性，主要針對人類CLDN6蛋白發(fā)揮特異性結(jié)合作用。 CLDN6作為緊密連接蛋白家族成員，在正常組織中表達(dá)受限，但在多種惡性腫瘤中異常高表達(dá)，如卵巢癌、睪丸癌、子宮內(nèi)膜癌等，成為極具潛力的腫瘤治療靶點(diǎn)。IMAB027作為首個(gè)靶向CLDN6的單克隆抗體類似物，早期臨床試驗(yàn)顯示其可通過抗體依賴性細(xì)胞毒性（ADCC）和補(bǔ)體依賴的細(xì)胞毒性（CDC）等機(jī)制誘導(dǎo)腫瘤細(xì)胞凋亡，單獨(dú)或聯(lián)合化療對CLDN6陽性實(shí)體瘤展現(xiàn)出良好的抗腫瘤活性。目前，相關(guān)研發(fā)聚焦于優(yōu)化生產(chǎn)工藝、降低毒性，以提高臨床應(yīng)用的安全性和可及性，為晚期CLDN6陽性腫瘤患者提供新的治療選擇。 CLDN6重組單克隆抗體是研究CLDN6生物學(xué)功能的重要工具。它助力分析CLDN6在細(xì)胞分化、腫瘤發(fā)生發(fā)展中的作用機(jī)制，例如通過檢測CLDN6在不同組織或細(xì)胞系中的表達(dá)水平，探討其與腫瘤侵襲、轉(zhuǎn)移的相關(guān)性。此外，該抗體還可用于構(gòu)建CLDN6靶向的腫瘤模型，為篩選新型CLDN6抑制劑或雙特異性抗體提供實(shí)驗(yàn)基礎(chǔ)，推動(dòng)CLDN6相關(guān)基礎(chǔ)研究向臨床轉(zhuǎn)化。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Claudin-6 antibody; Claudin6 antibody; CLD6_HUMAN antibody; CLDN 6 antibody; CLDN6 antibody; OTTHUMP00000159248 antibody; Skullin 2 antibody; Skullin antibody; UNQ757/PRO1488 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLDN6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
  • 基因功能參考文獻(xiàn)：
    1. Antibodies recognizing native CLDN6 as displayed on cell surfaces and mediating complement-dependent cytotoxicity were elicited in vaccinated animals. The data suggest applications of CLDN6 displaying Virus-like particles in cancer immunotherapy. PMID: 29131519
    2. these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4, -6, -7 and -9 also increases PMID: 29031421
    3. Study provides evidence that high expression of CLDN6 confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53. PMID: 29116019
    4. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID: 29159771
    5. we demonstrated that the downregulation of CLDN6 is regulated through promoter methylation by DNMT1, which depends on the SMAD2 pathway, and that CLDN6 is a key regulator in the SMAD2/DNMT1/CLDN6 pathway to inhibit EMT, migration and invasion of breast cancer cells PMID: 28867761
    6. In conclusion, this information from bioinformatics analysis will help future attempts to better understand CLDN6 regulation and functions. PMID: 28656265
    7. high expression of CLDN 6 was observed in approx. 65% of the myxofibrosarcomas, whereas the benign soft tissue tumors did not show a high expression of CLDN 6. The expression of CLDN 6 in the myxofibrosarcomas was significantly higher than those of other tumor specimens. Among the myxofibrosarcomas, the high expression of CLDN 6 was correlated with high FNCLCC grades and high AJCC stages. PMID: 28476380
    8. Results show that DNA methylation down-regulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, consequently promoting migratory and invasive phenotype in breast cancer cells. PMID: 27461117
    9. Cldn6 was decreased in alveolar type II-like epithelial cells (A549) and primary small airway epithelial cells when exposed to cigarette smoke ext PMID: 27982694
    10. suggest that claudin-6 induces MMP-2 activation through claudin-1 membrane expression PMID: 27914788
    11. Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry. PMID: 26561856
    12. The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues. PMID: 26191261
    13. High levels of CLDN6 are associated with non-small-cell lung cancer. PMID: 24710653
    14. The expression of claudin-6 was down regulated in gastric cancer tissue. PMID: 23919729
    15. Only some hepatitis C virus strains efficiently use CLDN6 for infection. PMID: 23775920
    16. This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture. PMID: 23778593
    17. Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. PMID: 23864633
    18. ASK1 signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer. PMID: 22925655
    19. Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas PMID: 22455563
    20. CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors. PMID: 21989342
    21. 17beta-E2 might regulate the expression of claudin-6 and inhibit the proliferation and migration of MCF-7 cells. PMID: 20388399
    22. Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line. PMID: 20874001
    23. CLDN6 may be a useful positive marker to help further identify atypical teratoid/rhabdoid tumors for diagnostic and treatment purposes PMID: 19220299
    24. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis PMID: 19960275
    25. The up-regulation of claudin-6 expression in MCF-7 breast cancer cells suppresses their malignant phenotypes with a correlation with the restoration of tight junction integrity. PMID: 20367941
    26. claudin-6, downregulates the malignant phenotype of breast carcinoma. PMID: 20215972
    27. Claudin 6 was not found in epithelioid glioblastomas or rhabdoid glioblastomas. PMID: 20118769
    28. CLDN6 and CLDN9, but not CLDN1, are expressed in peripheral blood mononuclear cells, an additional site of HCV replication. PMID: 17804490
    29. claudin-6 and claudin-9 expressed in CD81+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes. PMID: 18234789
    30. CLDN6, clustered with CLDN9 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

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  • 亞細(xì)胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2048

    OMIM: 615798

    KEGG: hsa:9074

    STRING: 9606.ENSP00000328674

    UniGene: Hs.533779



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