日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 科研級(jí)生物類(lèi)似抗體
  4. CLDN6 (IMAB027 Biosimilar) Recombinant Monoclonal Antibody

CLDN6 (IMAB027 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA005508MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLDN6 (IMAB027 Biosimilar Antibody) 重組單克隆抗體是一種針對(duì) Claudin-6（CLDN6）蛋白，其別名為 Claudin-6 抗體、Claudin6 抗體、CLD6_HUMAN 抗體、CLDN 6 抗體、OTTHUMP00000159248 抗體、Skullin 2 抗體、Skullin 抗體及 UNQ757/PRO1488 抗體。該抗體以重組人 CLDN6 蛋白制備，具有高度的種屬反應(yīng)性，專(zhuān)門(mén)針對(duì)人類(lèi) CLDN6 靶點(diǎn)發(fā)揮作用。 CLDN6 作為緊密連接蛋白家族成員，在多種惡性腫瘤中存在異常高表達(dá)，而在正常成人組織中表達(dá)受限，使其成為理想的腫瘤治療靶點(diǎn)。IMAB027 作為原研抗體類(lèi)似物，已在臨床試驗(yàn)中展現(xiàn)出對(duì) CLDN6 陽(yáng)性實(shí)體瘤（如卵巢癌、睪丸癌等）的治療潛力，其開(kāi)發(fā)旨在通過(guò)保留藥物的結(jié)構(gòu)和生物活性，降低治療成本，擴(kuò)大患者可及性。目前，IMAB027 生物類(lèi)似藥正處于臨床前比對(duì)研究或早期臨床試驗(yàn)階段，重點(diǎn)驗(yàn)證其與原研藥在藥代動(dòng)力學(xué)、安全性及有效性方面的一致性。 CLDN6 重組單克隆抗體為腫瘤生物學(xué)研究提供了重要工具。研究人員可利用該抗體檢測(cè) CLDN6 在不同組織和細(xì)胞系中的表達(dá)水平，探索其在腫瘤發(fā)生、侵襲和轉(zhuǎn)移中的分子機(jī)制；通過(guò)實(shí)驗(yàn)，分析 CLDN6 與腫瘤預(yù)后的相關(guān)性；此外，該抗體還可用于構(gòu)建 CLDN6 靶向類(lèi)似物遞送系統(tǒng)或雙特異性抗體的前期研發(fā)，為開(kāi)發(fā)新型腫瘤治療策略奠定基礎(chǔ)。其針對(duì)人類(lèi) CLDN6 的特異性結(jié)合能力，確保了實(shí)驗(yàn)結(jié)果的可靠性和準(zhǔn)確性，適用于基礎(chǔ)研究及轉(zhuǎn)化醫(yī)學(xué)領(lǐng)域的多種實(shí)驗(yàn)場(chǎng)景。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Claudin-6 antibody; Claudin6 antibody; CLD6_HUMAN antibody; CLDN 6 antibody; CLDN6 antibody; OTTHUMP00000159248 antibody; Skullin 2 antibody; Skullin antibody; UNQ757/PRO1488 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLDN6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
  • 基因功能參考文獻(xiàn)：
    1. Antibodies recognizing native CLDN6 as displayed on cell surfaces and mediating complement-dependent cytotoxicity were elicited in vaccinated animals. The data suggest applications of CLDN6 displaying Virus-like particles in cancer immunotherapy. PMID: 29131519
    2. these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4, -6, -7 and -9 also increases PMID: 29031421
    3. Study provides evidence that high expression of CLDN6 confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53. PMID: 29116019
    4. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID: 29159771
    5. we demonstrated that the downregulation of CLDN6 is regulated through promoter methylation by DNMT1, which depends on the SMAD2 pathway, and that CLDN6 is a key regulator in the SMAD2/DNMT1/CLDN6 pathway to inhibit EMT, migration and invasion of breast cancer cells PMID: 28867761
    6. In conclusion, this information from bioinformatics analysis will help future attempts to better understand CLDN6 regulation and functions. PMID: 28656265
    7. high expression of CLDN 6 was observed in approx. 65% of the myxofibrosarcomas, whereas the benign soft tissue tumors did not show a high expression of CLDN 6. The expression of CLDN 6 in the myxofibrosarcomas was significantly higher than those of other tumor specimens. Among the myxofibrosarcomas, the high expression of CLDN 6 was correlated with high FNCLCC grades and high AJCC stages. PMID: 28476380
    8. Results show that DNA methylation down-regulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, consequently promoting migratory and invasive phenotype in breast cancer cells. PMID: 27461117
    9. Cldn6 was decreased in alveolar type II-like epithelial cells (A549) and primary small airway epithelial cells when exposed to cigarette smoke ext PMID: 27982694
    10. suggest that claudin-6 induces MMP-2 activation through claudin-1 membrane expression PMID: 27914788
    11. Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry. PMID: 26561856
    12. The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues. PMID: 26191261
    13. High levels of CLDN6 are associated with non-small-cell lung cancer. PMID: 24710653
    14. The expression of claudin-6 was down regulated in gastric cancer tissue. PMID: 23919729
    15. Only some hepatitis C virus strains efficiently use CLDN6 for infection. PMID: 23775920
    16. This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture. PMID: 23778593
    17. Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. PMID: 23864633
    18. ASK1 signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer. PMID: 22925655
    19. Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas PMID: 22455563
    20. CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors. PMID: 21989342
    21. 17beta-E2 might regulate the expression of claudin-6 and inhibit the proliferation and migration of MCF-7 cells. PMID: 20388399
    22. Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line. PMID: 20874001
    23. CLDN6 may be a useful positive marker to help further identify atypical teratoid/rhabdoid tumors for diagnostic and treatment purposes PMID: 19220299
    24. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis PMID: 19960275
    25. The up-regulation of claudin-6 expression in MCF-7 breast cancer cells suppresses their malignant phenotypes with a correlation with the restoration of tight junction integrity. PMID: 20367941
    26. claudin-6, downregulates the malignant phenotype of breast carcinoma. PMID: 20215972
    27. Claudin 6 was not found in epithelioid glioblastomas or rhabdoid glioblastomas. PMID: 20118769
    28. CLDN6 and CLDN9, but not CLDN1, are expressed in peripheral blood mononuclear cells, an additional site of HCV replication. PMID: 17804490
    29. claudin-6 and claudin-9 expressed in CD81+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes. PMID: 18234789
    30. CLDN6, clustered with CLDN9 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2048

    OMIM: 615798

    KEGG: hsa:9074

    STRING: 9606.ENSP00000328674

    UniGene: Hs.533779



×
生命科學(xué)計(jì)算平臺(tái)