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  4. CLDN1 (lixudebart Biosimilar) Recombinant Monoclonal Antibody

CLDN1 (lixudebart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA005490MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLDN1（lixudebart Biosimilar Antibody）重組單克隆抗體是一種針對緊密連接蛋白Claudin-1（CLDN1），其別名為Claudin-1抗體、CLD1抗體、CLDN1_HUMAN抗體、ILVASC抗體、SEMP1抗體等，也可稱為衰老相關(guān)上皮膜蛋白抗體。該抗體以重組人CLDN1蛋白制備，具有高度的種屬反應(yīng)性，主要針對人類CLDN1蛋白發(fā)揮特異性結(jié)合作用。 lixudebart是一款 first - in - class 靶向 CLDN1 的原創(chuàng)單克隆抗體，并非生物類似藥。其臨床研究圍繞 CLDN1 作為上皮細胞緊密連接關(guān)鍵組成蛋白的特性展開，針對病理狀態(tài)下暴露于緊密連接外的異常 CLDN1，探索對肝纖維化、ANCA 相關(guān)性血管炎、特發(fā)性肺纖維化等疾病的治療潛力，通過阻斷 CLDN1 介導的纖維化信號、改善組織微環(huán)境發(fā)揮作用；目前該抗體研發(fā)的藥物僅處于 Ⅰ/Ⅱ 期臨床試驗階段，尚未獲批臨床應(yīng)用。CLDN1的表達異常與多種疾病的發(fā)生發(fā)展密切相關(guān)，在肝癌、乳腺癌、胰腺癌等惡性腫瘤中呈現(xiàn)異常高表達，可能通過調(diào)控細胞增殖、遷移及侵襲能力參與腫瘤進展。因此，lixudebart Biosimilar藥物有望成為腫瘤診斷和治療的潛在藥物，目前相關(guān)臨床前研究已初步驗證其在抑制腫瘤細胞侵襲和轉(zhuǎn)移方面的潛力，未來可能為癌癥精準治療提供新策略。 該抗體憑借對人CLDN1蛋白的高特異性和親和力，被廣泛應(yīng)用于細胞生物學、分子生物學及病理學等研究領(lǐng)域。例如，在實驗中，可用于檢測CLDN1蛋白在正常組織與病變組織中的表達差異，助力闡明其在生理病理過程中的作用機制。此外，通過抗體中和實驗或基因編輯技術(shù)結(jié)合該抗體，能夠深入探究CLDN1在緊密連接形成、上皮細胞極性維持及屏障功能調(diào)控中的分子機制，為相關(guān)疾病的基礎(chǔ)研究提供重要工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Claudin-1 antibody; Claudin1 antibody; CLD 1 antibody; CLD1 antibody; CLD1_HUMAN antibody; CLDN 1 antibody; Cldn1 antibody; ILVASC antibody; SEMP 1 antibody; SEMP1 antibody; Senescence associated epithelial membrane protein 1 antibody; Senescence associated epithelial membrane protein antibody; Senescence-associated epithelial membrane protein antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLDN1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.; (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
  • 基因功能參考文獻：
    1. the accumulation and toxicity of doxorubicin were rescued by CLDN1 siRNA in A549R cells. We suggest that CLDN1 is upregulated by CDDP resistance through activation of a PI3K/Akt/NF-kappaB pathway, resulting in the inhibition of penetration of anticancer drugs into the inner area of spheroids PMID: 29524521
    2. Our data indicate that CLDN1 targeting with an anti-CLDN1 mAb results in decreased growth and survival of CRC cells. This suggests that CLDN1 could be a new potential therapeutic target. PMID: 28659146
    3. Human Growth Hormone Inhibits CLAUDIN-1 Expression Through Activation of Signal Transducer and Activator of Transcription 3 (STAT3). PMID: 28617312
    4. CLDN1 promotes invasion and metastasis in cervical cancer cells via the expression of EMT/invasion-related genes. PMID: 27974683
    5. Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. PMID: 28055967
    6. Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions PMID: 27259233
    7. association of genetic polymorphisms of claudin-1 with small vessel vascular dementia PMID: 28273404
    8. Glutamine increased claudin-1 expression in the colonic mucosa of patients with irritable bowel syndrome. PMID: 25972430
    9. CLDN-1 promoted the migration and EMT through the Notch signaling pathway. PMID: 28316062
    10. In human lung tissue, Claudin-1 is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 are increased by RBFOX3. PMID: 28126724
    11. Data show that miR-30a could bind to the 3'-untranslted region of Slug mRNA and increased expression of claudins, a family of tight junction transmembrane proteins. PMID: 26918943
    12. These findings indicate a previously unrecognized mechanism that miR-142-5p, targeting CLDN1, plays an important role in Hashimoto's thyroiditis pathogenesis. PMID: 27277258
    13. Here, the authors identified an interaction between claudin-1 and Sec24C, a cargo-sorting component of the coat protein complex II (COPII) vesicular transport system. PMID: 28679754
    14. Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma cells. PMID: 27436828
    15. Increased expression of intestinal epithelial claudin-1 with downregulation of claudin-3 has been observed in intestinal inflammatory disorders. PMID: 28493289
    16. Studies indicate claudin 1 (CLDN-1) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics. PMID: 28415141
    17. Data show that the charge of Lys65 in claudin 1 (Cldn1) and Glu158 in claudin 3 (Cldn3), and of Gln57 in claudin 5 (Cldn5) are necessary for tight junction (TJ) strand formation. PMID: 28415153
    18. Studies indicate that claudin-1 accumulate in early endosomes in both epithelial and endothelial cells. PMID: 28415156
    19. Claudin-low tumors were associated with young age of onset, higher tumor grade, larger tumor size, extensive lymphocytic infiltrate and a circumscribed tumor margin. Patients with claudin-low tumors had a worse overall survival when compared to patients with luminal A type breast cancer. PMID: 28045912
    20. These results revealed that CLDN1 contributed to cancer stem cell features of hepatocellular carcinoma, which was altered by TMPRSS4 expression via ERK1/2 signaling pathway, providing promising targets for novel specific therapies. PMID: 28651932
    21. Data suggest that epithelial-mesenchymal transition (EMT) is regulated by ZMYND8 (receptor for activated protein kinase C) which selectively activates gene promoters of CLDN1 (claudin 1) and CDH1 (E-cadherin) in breast cancer cells; thus, the presence of ZMYND8 could be implicated in maintaining epithelial phenotype of cells; ZMYND8 regulates invasion/migration of breast cancer cells. PMID: 28432260
    22. The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1. PMID: 28342862
    23. TNF-alpha mediated regulation of claudin-1 and tumorigenic abilities of colon cancer cells. PMID: 27742576
    24. CLDN1 is significantly hypomethylated in tumor samples and that the membrane staining intensity for claudin 1, 4, and 7 is significantly lower in colorectal cancer tissues than in adjacent nonneoplastic tissue. PMID: 28381183
    25. CLDN1 rather than variants in FLG may be involved in the susceptibility of AD in the Ethiopian population PMID: 27581203
    26. CLDN1 overexpression is a good prognostic factor in NSCLC. PMID: 27687058
    27. Studies showthat CLDN1 is downregulated in lung adenocarcinoma and that low CLDN1 messenger ribonucleic acid (mRNA) expression leads to shorter overall survival. PMID: 27766775
    28. The loss of claudin-1 appears to be involved in the pathogenesis of pterygium PMID: 26820697
    29. autotypic tight junctions molecular composition, like claudin-1 and occludin expression could influence the demyelinating process by altering the permeability of the blood-nerve barrier. PMID: 26662145
    30. High CLDN1 expression is associated with Cervical cancer. PMID: 26463354
    31. Claudin-1 expression was correlated with lymphatic microvessel generation in hypopharyngeal squamous cell carcinoma and with patient survival. PMID: 26436506
    32. High CLAUDIN-1 expression is associated with metastasis in follicular thyroid carcinoma. PMID: 26219679
    33. The highest expression of claudin-1 was observed in well-differentiated oral squamous cell carcinomas, whereas poorly differentiated tumors exhibited mostly no expression of claudin-1. PMID: 25517868
    34. Report genetic polymorphism of TJ component claudin-1 and their haplotypes are associated with leukoaraiosis. PMID: 25956626
    35. Using a human liver-chimeric mouse model, we show that a monoclonal antibody specific for the TJ protein claudin-1 (ref. 7) eliminates chronic HCV infection without detectable toxicity PMID: 25798937
    36. delocalization of claudin-1 induced by PKC phosphorylation contributes to metastatic capacity of osteosarcoma cells PMID: 26361141
    37. The expressions of MARVELD2, CLDN1 and CLDN3 mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability. PMID: 25319490
    38. There was no difference in the frequency of fractures or renal lithiasis between the rs219780 genotype groups in PHPT patients. Nor was there any relationship between the T or C alleles and BMD or biochemical parameters. PMID: 26554238
    39. CLD1-mediated hepatoma cell invasiveness occurs via heat shock factor 1 (HSF1) activation. PMID: 26157141
    40. Findings suggest that CLDN1 is oncogenic in gastric cancer and its malignant potential may be attributed in part to regulation of anoikis, by mediating membrane beta-catenin-regulated cell-cell adhesion and cell survival. PMID: 25544763
    41. reduction of claudin-1 expression may contribute to the progression of gastric tumors PMID: 25755790
    42. Data from live-cell imaging suggest at least two different cis-interaction interfaces within CLDN3 homopolymers as well as within CLDN1/CLDN3 heteropolymers. PMID: 25849148
    43. Suggest that claudin 1 is an important messenger that regulates TNF-alpha-induced gene expression and migration in gastric cancer cells. PMID: 25548484
    44. The findings suggest that down regulated CLDN1 and CLDN5 genes have potential relevance in relation to the progression of glioblastoma multiforme. PMID: 25345514
    45. Positive expressions of Claudin-1 in retinoblastoma were fewer than those in retina; higher positive expressions were found in differentiated tissues than in undifferentiated tissues; Claudin-1 expressed more positively in optic nerves without invasion. PMID: 26122225
    46. findings suggest that homozygous CD81 rs708564 TT may be a genetic modifier for avoiding HCV infection whether as a sole single nucleotide polymorphism or combined with the CLDN1 rs893051 GG genotype PMID: 25934191
    47. Our results indicate that CLDN4 expression is correlated with poor prognosis, and CLDN1 expression may be an indicator of recurrence of oral squamous cell carcinoma. PMID: 25964581
    48. CLDN1-negative phenotype predicts a high risk of recurrence and death in triple-negative breast cancer. PMID: 25393310
    49. dystopic subcellular localizations of Snail-1 and claudin-1 may participate in changes of cellular morphology and behavior which might be associated with altered effectory pathways of proteins and thus substantially contribute to the cancer development. PMID: 22408413
    50. Data show that C-terminal domain of Clostridium perfringens enterotoxin (cCPE)-binding to claudin 1 and claudin 5 is prevented by two residues in extracellular loop 2 of Cld1 (Asn(150) and Thr(153)) and Cld5 (Asp(149) and Thr(151)). PMID: 25342221

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  • 相關(guān)疾?。?/div>
    Ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH)
  • 亞細胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2032

    OMIM: 603718

    KEGG: hsa:9076

    STRING: 9606.ENSP00000295522

    UniGene: Hs.439060



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