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  4. CFD (lampalizumab Biosimilar) Recombinant Monoclonal Antibody

CFD (lampalizumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA005271MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CFD（lampalizumab Biosimilar Antibody）重組單克隆抗體是一種針對補體因子D（CFD），其靶點CFD具有多種別名，包括Complement factor D、EC 3.4.21.46、Adipsin、C3轉(zhuǎn)化酶激活劑、備解素因子D等，在補體系統(tǒng)替代途徑中發(fā)揮關(guān)鍵調(diào)控作用。該抗體以重組人CFD蛋白制備，具有高度的人源種屬反應(yīng)性，可特異性結(jié)合并抑制人CFD的生物學活性。 lampalizumab作為類似物，其作用靶點CFD作為補體系統(tǒng)的重要調(diào)節(jié)因子，其異常激活與多種疾病的發(fā)生發(fā)展密切相關(guān)，如年齡相關(guān)性黃斑變性（AMD）、非典型溶血性尿毒癥綜合征（aHUS）等。lampalizumab曾在年齡相關(guān)性黃斑變性（AMD）的臨床試驗中，探索通過靶向抑制補體因子D（CFD）活性、減少補體系統(tǒng)過度激活，進而減輕補體介導的視網(wǎng)膜損傷；而以CFD為作用靶點的候選藥物（含生物類似藥），研發(fā)目標是為患者提供更可及的治療選擇，目前相關(guān)臨床研究主要集中于驗證此類藥物與陽性對照藥lampalizumab的生物相似性，以及在各類補體相關(guān)疾病中的療效與安全性。 CFD重組單克隆抗體因其對人CFD的高特異性和親和力，成為補體系統(tǒng)功能研究的重要工具。研究者可利用該抗體在細胞模型和動物模型中特異性阻斷CFD活性，深入探究補體替代途徑在免疫調(diào)節(jié)、炎癥反應(yīng)及疾病病理機制中的作用。此外，其基于重組人CFD蛋白的設(shè)計確保了實驗結(jié)果的可靠性，適用于蛋白質(zhì)相互作用分析、信號通路調(diào)控研究等基礎(chǔ)為開發(fā)新的補體靶向治療策略提供實驗支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Complement factor D；EC 3.4.21.46；Adipsin；C3 convertase activator；Properdin factor D , CFD, DF PFD
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CFD protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
  • 基因功能參考文獻：
    1. MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked. PMID: 27535802
    2. disturbance of reciprocal relationships between adipsin and leptin in obesity is associated with the development of insulin resistance PMID: 28864895
    3. TZDs (pioglitazone, rosiglitazone, and ciglitazone) slow tumor cell growth in vitro and in vivo with decreases in cell proliferation and increases in PPARg and adipsin PMID: 28219679
    4. The strong association of PLIN1, CFD and ADIPOQ genes with adipogenesis prompted authors to study the influence the bone health status as evaluated by quantitative ultrasound (QUS) bone densitometer in a North Indian cohort. Overall, ADIPOQ (rs1501299 and rs3774261) and combined cluster of PLIN1 rs2304796 and rs2304795) and CFD (rs1683563) demonstrated correlation. PMID: 28189761
    5. our findings set up a novel mechanism for FABP4, adipsin and adiponectin through gut microbiota mediating expression in gut Paneth cells. PMID: 26687459
    6. Overall adipsin levels among male asbestos industry workers were significantly higher than among control subjects. PMID: 25840635
    7. Data indicate that a urinary protein, adipsin, was significantly increased in patients with preeclampsia. PMID: 24958499
    8. Study demonstrates that T2DM patients with beta cell failure are deficient in adipsin. PMID: 24995977
    9. Complement factor D (FD) is activated by its substrate through interactions outside the active site which lock the unbound native state into an ordered inactive conformation via the self-inhibitory loop in FD. PMID: 24598742
    10. We demonstrate novel secretion of adipsin and ASP by placental Hofbauer cells. PMID: 23956345
    11. Increased activation of the alternative complement pathway in vitreous was controlled by disease stage and genetic variation in the complement pathway, supporting a role for complement activation in macular degeneration disease pathogenesis. PMID: 22930722
    12. Anti factor D Fab fragment inhibits FD proteolytic function by interfering with macromolecular substrate access rather than by inhibiting FD catalysis. PMID: 22362762
    13. CFD regulates activation of the alternative complement pathway, which is implicated in age related macular degeneration pathogenesis. PMID: 22003108
    14. CFD may not play a major role in the genetic susceptibility to age-related macular degeneration. PMID: 21139680
    15. crystal structure of C3bB at 4 A and complex with factor D at 3.5 A; data show how factor B binding to C3b forms open "activation" state of C3bB; Factor D binds open conformation of factor B through a site distant from the catalytic center PMID: 21205667
    16. As adiponectin and adipsin levels in CSF did not correlate with their levels in plasma, it seems that there could be a secondary intrathecal synthesis of these adipocytokines in multiple sclerosis PMID: 19538214
    17. increased serum levels in patients with seasonal allergic rhinitis PMID: 19699327

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  • 相關(guān)疾?。?/div>
    Complement factor D deficiency (CFDD)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2771

    OMIM: 134350

    KEGG: hsa:1675

    STRING: 9606.ENSP00000332139

    UniGene: Hs.155597



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