CEACAM5/CEACAM6（NEO-201 Biosimilar Antibody）重組單克隆抗體是一種針對人癌胚抗原相關(guān)細(xì)胞黏附分子5和6，其別名包括癌胚抗原抗體、CD66e抗體、CEA抗體、CEACAM5抗體、CEACAM6抗體、CD66c抗體、NCA抗體等。該抗體以重組人CEACAM5/CEACAM6蛋白制備，具有高度的人源種屬反應(yīng)性，專門用于識別人源樣本中的CEACAM5和CEACAM6蛋白。 CEACAM5和CEACAM6作為重要的腫瘤相關(guān)抗原，在多種上皮源性腫瘤中高表達(dá)，如結(jié)直腸癌、胃癌、肺癌等，與腫瘤的發(fā)生發(fā)展、侵襲轉(zhuǎn)移及預(yù)后密切相關(guān)。因此，靶向CEACAM5/CEACAM6類似物被廣泛應(yīng)用于腫瘤的診斷、療效監(jiān)測及靶向治療。例如，基于CEACAM5/CEACAM6靶點的免疫檢測技術(shù)可用于腫瘤標(biāo)志物的定量分析，輔助臨床早期診斷和病情評估；同時，靶向CEACAM5/CEACAM6的治療藥物研發(fā)也備受關(guān)注，通過特異性結(jié)合腫瘤細(xì)胞表面的CEACAM5/CEACAM6，可能實現(xiàn)精準(zhǔn)殺傷腫瘤細(xì)胞，減少對正常組織的損傷，目前相關(guān)臨床試驗正在探索其在晚期實體瘤治療中的安全性和有效性。 在該抗體是研究CEACAM5和CEACAM6生物學(xué)功能的關(guān)鍵工具。科研人員可利用其特異性結(jié)合能力，通過實驗，在細(xì)胞水平和組織水平檢測CEACAM5/CEACAM6的表達(dá)定位、表達(dá)水平變化及其與信號通路的關(guān)聯(lián)，深入探究這兩種分子在腫瘤微環(huán)境調(diào)控、細(xì)胞黏附、免疫逃逸等生理病理過程中的作用機(jī)制，為開發(fā)新的腫瘤治療靶點和策略提供實驗依據(jù)。此外，該抗體也可用于構(gòu)建腫瘤動物模型，評估靶向CEACAM5/CEACAM6類似物遞送系統(tǒng)或免疫治療方案的體內(nèi)效果。

P06731&P40199

CEACAM5/CEACAM6

Carcinoembryonic antigen antibody; Carcinoembryonic antigen-related cell adhesion molecule 5 antibody; CD66e antibody; CEA antibody; Ceacam5 antibody; CEAM5_HUMAN antibody; DKFZp781M2392 antibody; Meconium antigen 100 antibody; OTTHUMP00000199032 antibody; OTTHUMP00000199033 antibody; OTTHUMP00000199034 antibody;Carcinoembryonic antigen related cell adhesion molecule 6 antibody; Carcinoembryonic antigen related cell adhesion molecule 6；non specific cross reacting antigen antibody; Carcinoembryonic antigen-related cell adhesion molecule 6 antibody; CD 66c antibody; CD66c antibody; CD66c antigen antibody; CEA LIKE PROTEIN antibody; CEACAM 6 antibody; CEACAM6 antibody; CEAL antibody; CEAM6_HUMAN antibody; MGC93832 antibody; NCA antibody; Non specific cross reacting antigen antibody; Non-specific crossreacting antigen antibody; Normal cross reacting antigen antibody; Normal cross-reacting antigen antibody

Human

Recombinant Human CEACAM5/CEACAM6 protein

Homo sapiens (Human)

Non-conjugated

Monoclonal

It differs from different batches. Please contact us to confirm it.

0.01M PBS，pH7.4

Liquid

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

In stock

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.