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  4. CDH6 (WO2016024195A1 Biosimilar) Recombinant Monoclonal Antibody

CDH6 (WO2016024195A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA005055MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CDH6（WO2016024195A1 Biosimilar Antibody）重組單克隆抗體是一種針對鈣粘蛋白-6（Cadherin-6），其別名為Kidney cadherin或K-cadherin，屬于鈣粘蛋白家族成員，主要在腎臟等組織中表達(dá)。該抗體以重組人CDH6蛋白制備，具有高度特異性，種屬反應(yīng)性明確為人類，為相關(guān)疾病的研究和治療提供了精準(zhǔn)的靶向工具。 針對CDH6類似物因其在腎臟發(fā)育及多種腫瘤中的異常表達(dá)而備受關(guān)注。研究表明，CDH6在腎細(xì)胞癌、卵巢癌等惡性腫瘤中高表達(dá)，與腫瘤侵襲、轉(zhuǎn)移及預(yù)后不良密切相關(guān)。作為其，針對CDH6類似物可模擬藥物發(fā)現(xiàn)的陽性對照的靶向結(jié)合能力，通過特異性識(shí)別CDH6分子，干擾腫瘤細(xì)胞間的黏附作用及信號(hào)傳導(dǎo)，從而抑制腫瘤生長和擴(kuò)散。目前，針對CDH6類似物的臨床試驗(yàn)主要聚焦于實(shí)體瘤治療，尤其在晚期腎細(xì)胞癌患者中，初步數(shù)據(jù)顯示其可顯著延長無進(jìn)展生存期，且安全性良好，為耐藥或難治性患者提供了新的治療選擇。 CDH6重組單克隆抗體是探索CDH6生物學(xué)功能的重要工具。借助該抗體，研究人員可通過技術(shù)，精準(zhǔn)檢測CDH6在正常組織及病變樣本中的表達(dá)水平與定位，深入分析其在腎臟發(fā)育、腫瘤發(fā)生機(jī)制中的作用。此外，該抗體還可用于構(gòu)建CDH6靶向的細(xì)胞模型或動(dòng)物模型，為篩選新型抗腫瘤藥物、驗(yàn)證治療靶點(diǎn)的有效性提供實(shí)驗(yàn)基礎(chǔ)。其高度的種屬特異性確保了在人類細(xì)胞及組織研究中的可靠性，推動(dòng)了從基礎(chǔ)研究到臨床轉(zhuǎn)化的快速推進(jìn)。 綜上，CDH6重組單克隆抗體不僅為CDH6相關(guān)疾病的臨床治療帶來新希望，也為生命科學(xué)領(lǐng)域的機(jī)制研究提供了關(guān)鍵工具，具有重要的價(jià)值和科研意義。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CDH6; Cadherin-6; Kidney cadherin; K-cadherin
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CDH6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能參考文獻(xiàn)：
    1. Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC PMID: 27593557
    2. The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells. PMID: 20634887
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1765

    OMIM: 603007

    KEGG: hsa:1004

    STRING: 9606.ENSP00000265071

    UniGene: Hs.124776



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