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  4. CDH11 (RG6125 Biosimilar) Recombinant Monoclonal Antibody

CDH11 (RG6125 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA005036MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CDH11 (RG6125 Biosimilar Antibody) 重組單克隆抗體是一種針對人CDH11蛋白，其別名包括CAD11抗體、Cadherin 11抗體、OB-cadherin抗體、OSF-4抗體等。該抗體以重組人CDH11蛋白制備，具有高度的種屬反應性，主要針對人類CDH11靶點。 CDH11作為鈣黏蛋白家族成員，在多種生理和病理過程中發(fā)揮關鍵作用，尤其與骨骼發(fā)育、腫瘤發(fā)生及纖維化疾病密切相關。目前，針對CDH11類似物已成為研究熱點，相關臨床試驗主要探索其在骨相關疾?。ㄈ绻琴|(zhì)疏松、骨轉移）和腫瘤治療中的潛力。例如，CDH11在骨肉瘤、乳腺癌等腫瘤中高表達，可能通過調(diào)控細胞黏附、侵襲和轉移參與疾病進展，因此相關藥物有望作為靶向治療藥物，抑制腫瘤細胞的擴散并改善患者預后。此外，其在纖維化疾病中的作用也在研究中，可能通過抑制CDH11介導的成纖維細胞活化，為肺纖維化、肝纖維化等疾病提供新的治療思路。 在CDH11重組單克隆抗體是研究CDH11蛋白功能的重要工具。由于其來源于重組人CDH11蛋白，且種屬反應性明確為人類，適用于人源細胞、組織樣本的實驗研究?？蒲腥藛T可利用該抗體進行實驗，檢測CDH11在不同組織和細胞中的表達水平與定位；也可通過免疫沉淀方法，深入探究其與其他蛋白的相互作用及信號通路機制。此外，在細胞模型和動物模型中，該抗體可用于功能阻斷實驗，研究CDH11在細胞分化、遷移、凋亡等生物學過程中的具體作用，為揭示相關疾病的分子機制提供實驗基礎。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CAD11 antibody; CAD11_HUMAN antibody; Cadherin 11 antibody; Cadherin 11 type 2 antibody; Cadherin 11 type 2 OB cadherin；osteoblast antibody; Cadherin-11 antibody; Cdh11 antibody; CDHOB antibody; OB antibody; OB-cadherin antibody; OBcadherin antibody; OSF-4 antibody; OSF4 antibody; Osteoblast cadherin antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CDH11 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能參考文獻：
    1. Elevated levels of PLAUR, a validated target gene, and CDH11 were confirmed in gastric tumors with low expression of miR-335. The 3'UTR of CDH11 was identified to be directly targeted by miR-335. PMID: 29075357
    2. This study reveals loss-of-function mutations in CDH11 as a probable cause of Elsahy-Waters syndrome phenotype. PMID: 28988429
    3. the observed CDH11 expression in active MM patients' peripheral blood was carried by circulating plasma cell clone(s), outgoing from an osteoblastic niche, conferring the disease transformation into symptomatic MM or its relapse. PMID: 27118219
    4. data show that ErbB2 and Akt are important for CNC migration and implicate other ErbB receptors and Akt-independent signaling pathways. Our findings provide the first example of a functional interaction between the extracellular domain of a type II classical cadherin and growth factor receptors PMID: 29190819
    5. Chemoresistant B-ALL patients are associated with increased methylation in ADAMTSL5 and CDH11. PMID: 28292214
    6. engagement of CDH11 through homophilic interactions, led to swift activation of the TGF-beta and ROCK pathways as evidenced by phosphorylation of downstream effectors. PMID: 27311482
    7. Cad-11 expression was significantly increased in pancreatic stellate cells and pancreatic cancer cells. PMID: 27855278
    8. Upregulation of miR-27b significantly accelerated the proliferation, cell cycle transition from G1 to S phase, migration and invasion of C33A cells, while downregulation of miR-27b suppressed the proliferation and invasion of HeLa cells PMID: 26706910
    9. observations suggest that clathrin-mediated internalization of Cad11 regulates surface trafficking of Cad11 and that dynamic turnover of Cad11 regulates the migratory function of Cad11 in prostate cancer cells. PMID: 26519476
    10. that U87-p75(NTR) cells express higher levels of Cdh-11 protein and that siRNA-mediated knockdown of Cdh-11 resulted in a significant decrease in p75(NTR)-mediated glioblastoma cell migration PMID: 26476273
    11. Invasive cancer cells had increased expression of mesenchymal markers cadherin 2 and 11 that localized with stromal cell cadherin 11, suggesting that these molecules are involved in stromal cell engraftment. PMID: 26046821
    12. Data suggest methylation status of gene promoters for CDH11 (cadherin 11) and BASP1 (brain abundant membrane attached signal protein 1) in tumor, skin, and metastatic tumor tissue may serve as prognostic biomarkers in patients with advanced melanoma. PMID: 25919928
    13. Cadherin-11 may be hyper-expressed in the peripheral blood of diffuse systemic scleroderma patients. PMID: 26121083
    14. Our results demonstrate that parathyroid hormone stimulates hematopoiesis through promoting the upregulation of CDH11 expression in bone marrow mesenchymal stromal cells PMID: 24648356
    15. High Cad-11 expression is associated with bone metastases of Ewing sarcoma. PMID: 26092671
    16. evidence for the involvement of CDH11 in Autism Spectrum Disorder which is consistent with the association of other cadherins with Autism Spectrum Disorder and neuropsychiatric diseases PMID: 24839052
    17. Cadherin 11, a miR-675 target, induces N-cadherin expression and epithelial-mesenchymal transition in melasma. PMID: 24940649
    18. This study evaluated the expression of CAD11 in the peripheral blood of rheumatoid arthritis patients and normal controls. PMID: 25173800
    19. High Cadherin-11 expression is associated with breast cancer. PMID: 24681547
    20. Data indicate that knockdown of CDH11 expression in primary human glioblastoma cells inhibits TGFbeta-stimulated migration. PMID: 23951053
    21. These data demonstrate that Cad-11 is a mediator of dermal fibrosis and TGFbeta production and suggest that Cad-11 may be a therapeutic target in systemic sclerosis. PMID: 24757152
    22. Data indicate that the interaction of mesenchymal stem cells (MSC) with fibroblast-like synoviocytes (FLS) via cadherin-11 may contribute to angiogenesis and chronic synovitis by enhancing the secretion of placental growth factor (PlGF). PMID: 24574497
    23. Thus, our results indicated abnormal expression of CD44V6, CDH11, and beta-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research. PMID: 23971040
    24. Results indicate the necessity of cadherin-11 for dystrophic calcific nodule formation, which proceeds through an Erk1/2-dependent pathway. PMID: 23162011
    25. The study of CDH11 5'-CpG island hypermethylation in primary tumours and lymph node metastases of cancer patients showed this epigenetic alteration to be significantly confined to the disseminated cells. PMID: 22374749
    26. Data indicate that CDH11 as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling, with frequent epigenetic inactivation in common carcinomas. PMID: 22139084
    27. These results show the functional significance of cadherin-11 expression in glioblastoma multiforme. PMID: 22267545
    28. CDH11 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas. PMID: 21722156
    29. CDH11 expression was assessed in lung tissue from idiopathic pulmonary fibrosis patients. PMID: 21990376
    30. increased expression in patients with rheumatoid arthritis PMID: 21798287
    31. cad-11 modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in RA. PMID: 21536877
    32. suppression of MUC1 by miR-145 causes a reduction of beta-catenin as well as the oncogenic cadherin 11 PMID: 19996288
    33. The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation PMID: 11775026
    34. CADH11 was evaluated as a biomarker at the protein level and was found to have increased expression in xenograft tumors after S11248 treatment. PMID: 14985702
    35. A 2.62 Mbp minimal region of genomic loss of chromosome 16q22 was found in retinoblastoma which contains a hotspot CDH11, implicating CDH11as a potential tumor suppressor gene in retinoblastoma. PMID: 15383628
    36. primary aneurysmal bone cysts are mesenchymal neoplasms exhibiting USP6 and/or CDH11 oncogenic rearrangements PMID: 15509545
    37. Review. Cadherin-11 expression confers upon cells a fundamental change in cellular behavior. Its expression on fibroblast-like synoviocytes may determine their behavior & differentiation. PMID: 15743489
    38. Together, these studies implicate cadherin-11 in synovial tissue and lining layer formation and provide an in vitro system to model fibroblast-like synoviocyte behavior and function in organizing the synovial tissue. PMID: 16651616
    39. Cadherin-11 is involved in the intercellular physical coupling of detrusor smooth muscle bladder cells and also of myofibroblasts. PMID: 17292535
    40. Overexpression of osteoblast cadherin is associated with breast cancer cell metastatic potential PMID: 18193170
    41. The results indicate that CDH11 may be useful as a prognostic marker of disease progression and survival in osteosarcoma. PMID: 18359978
    42. cadherin-11 promotes homing and migration to bone and osteoclastogenesis through mediating the homophilic interactions of breast cancer cells with marrow stromal/osteoblastic cells, thereby enhancing bone metastases. PMID: 18575746
    43. These findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone. PMID: 18708358
    44. Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation PMID: 18821672
    45. Cadherin-11 and fascin might be useful markers for recurrence of pleomorphic adenomas. PMID: 19133007
    46. Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR PMID: 19274078

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  • 相關疾病：
    A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1750

    OMIM: 600023

    KEGG: hsa:1009

    STRING: 9606.ENSP00000268603

    UniGene: Hs.116471



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