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  4. CD96 (US20200199227A1 Biosimilar) Recombinant Monoclonal Antibody

CD96 (US20200199227A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004971MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    CD96 (US20200199227A1 Biosimilar Antibody) 重組單克隆抗體是一種針對CD96分子，其來源于重組人CD96蛋白，主要與人種屬發(fā)生特異性反應。CD96作為T細胞表面蛋白，又被稱為T細胞表面抗原CD96、T細胞活化晚期表達增加蛋白或CD抗原CD96，在免疫調節(jié)中發(fā)揮重要作用。 CD96作為免疫檢查點分子，其藥物的研發(fā)聚焦于腫瘤免疫治療領域。研究表明，CD96與腫瘤微環(huán)境中的配體相互作用可能抑制T細胞的抗腫瘤活性，通過阻斷這一通路有望增強免疫系統對腫瘤細胞的識別和清除能力。目前相關臨床前研究已驗證其在多種實體瘤及血液腫瘤模型中的抗腫瘤潛力，部分臨床試驗正探索其單藥或聯合其他免疫抑制劑的治療效果，為癌癥患者提供新的治療選擇。 該抗體可用于CD96分子的功能研究、免疫細胞表型分析及相關信號通路機制探討。借助其對人CD96的特異性結合能力，研究人員能夠深入探究CD96在T細胞活化、免疫耐受及腫瘤免疫逃逸中的作用機制，為開發(fā)基于CD96靶點的新型治療策略提供實驗基礎。同時，作為其，其研發(fā)過程嚴格遵循其的技術要求，為后續(xù)臨床轉化及規(guī)?；a奠定了質量和安全性基礎。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CD96 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
  • 基因功能參考文獻：
    1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
    2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
    3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
    4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
    5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
    6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
    7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
    8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
    9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
    10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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  • 相關疾病：
    C syndrome (CSYN)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
  • 數據庫鏈接：

    HGNC: 16892

    OMIM: 211750

    KEGG: hsa:10225

    STRING: 9606.ENSP00000283285

    UniGene: Hs.142023



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