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  4. CD93 (WO 2021/247769 A1 Biosimilar) Recombinant Monoclonal Antibody

CD93 (WO 2021/247769 A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA865099MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD93 (WO 2021/247769 A1 Biosimilar Antibody) 重組單克隆抗體是一種針對CD93分子，其別名為C1q受體1抗體、C1q/MBL/SPA受體抗體、C1qR抗體、C1QR1_HUMAN抗體、CDw93抗體、補(bǔ)體成分1q亞組分受體1抗體、基質(zhì)重塑相關(guān)蛋白4抗體等。該抗體以重組人CD93蛋白制備，具有明確的抗原特異性，可特異性識(shí)別并結(jié)合CD93分子。 針對CD93靶點(diǎn)類似物的臨床應(yīng)用研究正在逐步推進(jìn)。CD93作為一種跨膜糖蛋白，參與血管生成、炎癥反應(yīng)及免疫調(diào)節(jié)等多種生理病理過程，其異常表達(dá)與腫瘤、心血管疾病、自身免疫性疾病等密切相關(guān)。因此，針對CD93靶點(diǎn)類似物有望成為相關(guān)疾病診斷和治療的潛在選擇。目前，相關(guān)藥物的臨床前研究已逐步開展，旨在探索其在腫瘤血管靶向治療、炎癥性疾病干預(yù)等方面的應(yīng)用價(jià)值，為后續(xù)臨床試驗(yàn)提供理論依據(jù)。 CD93重組單克隆抗體可用于多種實(shí)驗(yàn)，如，助力研究人員深入探究CD93分子的生物學(xué)功能及其在疾病發(fā)生發(fā)展中的作用機(jī)制。該抗體對人及食蟹猴具有種屬反應(yīng)性，適用于在這兩種物種的細(xì)胞、組織樣本中進(jìn)行CD93分子的檢測與定位，為跨物種的基礎(chǔ)研究和轉(zhuǎn)化醫(yī)學(xué)研究提供了可靠的工具支持。隨著對CD93功能研究的不斷深入，該抗體將在生命科學(xué)研究領(lǐng)域發(fā)揮重要作用，推動(dòng)相關(guān)疾病的機(jī)制研究和新藥研發(fā)進(jìn)程。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C1q receptor 1 antibody; C1q/MBL/SPA receptor antibody; C1qR antibody; C1qR(p antibody; C1qr1 antibody; C1QR1_HUMAN antibody; C1qRp antibody; CD93 antibody; CD93 antigen antibody; CD93 molecule antibody; CDw93 antibody; Complement component 1 q subcomponent receptor 1 antibody; Complement component C1q receptor antibody; dJ737E23.1 antibody; ECSM3 antibody; Matrix remodeling associated protein 4 antibody; Matrix remodelling associated 4 antibody; Matrix-remodeling-associated protein 4 antibody; MXRA4 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD93 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
  • 基因功能參考文獻(xiàn)：
    1. Report increased CD93 expression in patients with chronic plaque psoriasis and propose the C allele of rs2749817 as a new risk allele for psoriasis. PMID: 28421233
    2. Results show that CD93 and MMRN2 are co-expressed in the blood vessels of various tumors and their interaction modulates the angiogenic process. PMID: 28912033
    3. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
    4. CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination PMID: 27529750
    5. Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli. The recombinant protein could alter LPS pro-inflammatory activity on THP1 cells. PMID: 27742562
    6. Vascular CD93 expression is elevated in nasopharyngeal carcinoma and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. PMID: 27255994
    7. both transmembrane and soluble CD93 are overexpressed in patients with neovascular Age-Related Macular Degeneration. PMID: 27859225
    8. Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU [chronic spontaneous urticaria ], AR[allergic rhinitis], and asthma. ICS [inhaled corticosteroid] use significantly diminished serum sCD93 levels in steroid-naive patients with BA[Bronchial asthma]. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation. PMID: 28332366
    9. Data show that CD93 antigen proved to be phosphorylated on tyrosine 628 and 644 following cell adhesion on laminin through dystroglycan. PMID: 26848865
    10. CD93 expression identifies a predominantly cycling, non-quiescent leukemia-initiating cell population in MLL-rearranged AML, providing opportunities for selective targeting and eradication of LSCs. PMID: 26387756
    11. The T/T genotype of SNP rs2749817 of CD93 is associated with disseminated cancer. PMID: 26008729
    12. CD93 is a key regulator of glioma angiogenesis and vascular function, acting via cytoskeletal rearrangements required for cell-cell and cell-matrix adhesion. PMID: 26363010
    13. These data support a mechanism whereby gC1qR plays an important role in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway. PMID: 25288439
    14. The data indicate that gC1qR inhibits viability, migration and proliferation of cervical squamous cells carcinoma via the p38 MAPK signalling pathway. PMID: 23052251
    15. Antibody-dependent enhancement of parvovirus B19 involves an alternative mechanism mediated by the heat-sensitive complement factor C1q and its receptor, CD93. PMID: 24807719
    16. Expression of CD93 on the lymphocyte population of peripheral blood cells from infants at 1 month after birth was also significantly decreased, compared with that for neonatal umbilical cord blood. PMID: 24033555
    17. HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma PMID: 23651874
    18. These data support a mechanism whereby gC1qR induces apoptosis through the mitochondrial and p53-dependent pathways in cervical squamous cell carcinoma. PMID: 23268996
    19. soluble EGF-like domain containing CD93 protein is a novel angiogenic factor acting on the endothelium PMID: 23272129
    20. [review] Following a comprehensive summary of CD93 expression patterns, this review focuses on recent findings that address the putative function of CD93 in inflammation and innate immunity. PMID: 22206251
    21. Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine. PMID: 21768350
    22. Results suggest that the plasma concentration of soluble CD93 is a potential novel biomarker for Coronary Artery Disease (CAD), including MI. PMID: 21332844
    23. expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood PMID: 20512406
    24. both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma. PMID: 19796797
    25. To clarify the cellular and molecular properties of C1qRp it has been demonstrated that C1q does not show enhanced binding to C1qRp-transfected cells, is not a receptor for C1q, and is identical to CD93 with functions relevant to intercellular adhesion. PMID: 11994479
    26. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential PMID: 12140365
    27. O-glycosylation is important in the stable cell surface expression of C1qRP/CD93 PMID: 12891708
    28. Taken together, these findings indicate that the expression of the CD93 molecule identified by CD93 mAb (mNI-11) is dramatically decreased on U937 cells with apoptotic properties PMID: 18094537
    29. RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells PMID: 18834607

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15855

    OMIM: 120577

    KEGG: hsa:22918

    STRING: 9606.ENSP00000246006

    UniGene: Hs.97199



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