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  4. CD79A (CN 112368021 A Biosimilar) Recombinant Monoclonal Antibody

CD79A (CN 112368021 A Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA004957MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD79A (CN 112368021 A Biosimilar Antibody) 重組單克隆抗體是一種針對(duì)人CD79A分子，其別名包括B淋巴細(xì)胞特異性MB1蛋白抗體、B細(xì)胞抗原受體復(fù)合物相關(guān)蛋白α鏈抗體、CD79a抗原抗體、免疫球蛋白相關(guān)α抗體等。該抗體以重組人CD79A蛋白制備，具有高度的人源種屬反應(yīng)性，主要用于特異性識(shí)別和結(jié)合人CD79A分子。 CD79A作為B細(xì)胞抗原受體（BCR）復(fù)合物的關(guān)鍵組成部分，在B細(xì)胞的發(fā)育、活化和信號(hào)轉(zhuǎn)導(dǎo)中發(fā)揮重要作用。相關(guān)研究表明，CD79A的異常表達(dá)或功能失調(diào)與多種B細(xì)胞惡性腫瘤（如非霍奇金淋巴瘤、慢性淋巴細(xì)胞白血病等）密切相關(guān)。因此，針對(duì)CD79A類似物被視為潛在的診斷標(biāo)志物和治療靶點(diǎn)，目前正被探索用于B細(xì)胞惡性腫瘤的靶向治療，通過特異性結(jié)合CD79A分子，抑制腫瘤細(xì)胞增殖或誘導(dǎo)其凋亡，為血液系統(tǒng)腫瘤的精準(zhǔn)治療提供新策略。 CD79A抗體廣泛應(yīng)用于免疫學(xué)和腫瘤學(xué)研究。例如，通過技術(shù)，可利用其特異性識(shí)別CD79A分子，用于B細(xì)胞的鑒定、分選及功能研究；在腫瘤模型構(gòu)建和藥物篩選中，CD79A抗體可幫助分析B細(xì)胞惡性腫瘤的發(fā)生機(jī)制，評(píng)估靶向藥物的療效及安全性；此外，其在免疫調(diào)節(jié)、自身免疫性疾病等研究中也具有重要應(yīng)用價(jià)值，為深入理解B細(xì)胞相關(guān)生理病理過程提供關(guān)鍵工具。 總之，CD79A (CN 112368021 A Biosimilar Antibody) 重組單克隆抗體憑借其高度的特異性和種屬反應(yīng)性，不僅為B細(xì)胞相關(guān)疾病的臨床診斷與治療研究奠定了基礎(chǔ)，也為生命科學(xué)領(lǐng)域的基礎(chǔ)研究提供了有力支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    B lymphocyte-specific MB1 protein antibody; B-cell antigen receptor complex-associated protein alpha chain antibody; CD 79a antibody; CD79a antibody; CD79a antigen；immunoglobulin-associated alpha antibody; CD79A antigen antibody; CD79a molecule; immunoglobulin-associated alpha antibody; CD79A_HUMAN antibody; Ig alpha antibody; Ig-alpha antibody; IGA antibody; IgM-alpha antibody; Immunoglobulin-associated alpha antibody; Ly54 antibody; MB-1 membrane glycoprotein antibody; MB1 antibody; Membrane-bound immunoglobulin-associated protein antibody; Surface IgM-associated protein antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD79A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
  • 基因功能參考文獻(xiàn)：
    1. The incidence of MYD88 and CD79B mutations in patients with CD5(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status. PMID: 27915469
    2. Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part. PMID: 24769851
    3. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    4. CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. PMID: 24146823
    5. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL. PMID: 21324920
    6. CD79a may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma PMID: 20102401
    7. Unlike the B29 octamer motif, the mb-1 octamer motif does not have the essential sequence required for OBF-1/Bob1 interaction, therefore its promoter is not transactivated by OBF-1/Bob1. PMID: 11907094
    8. B cell-restricted mb-1 gene: expression, function, and lineage infidelity. Review. PMID: 12403343
    9. There is a somatic hypermutation of this gene in B-cell lymphoma and multiple myeloma. PMID: 12651942
    10. Results indicate that PAX5 is a more specific marker than CD79a for B-cell ALL diagnosis. PMID: 15492262
    11. lower levels of B-cell receptor surface expression observed in chronic lymphocytic leukemia are accounted for by an impaired glycosylation and folding of the mu and CD79a chains. PMID: 15591116
    12. FISH findings indicate that CD79a, despite its specificity for B-cell differentiation, represented the aberrant presence of a B-cell antigen in leukemias of distinct myeloid linage. PMID: 16271957
    13. Acute leukemia with t(8;21) coexpresses CytCD79a represent biphenotypic acute leukemia. PMID: 17350472
    14. Anti-CD79b antibodies downregulated surface B-cell receptor and were trafficked to the lysosomal-like major histocompatibility complex class II-positive compartment of a mouse xenograft model of non-Hodgkin lymphoma. PMID: 17374736
    15. Ig-alpha was phosphorylated in all myeloma IgG BCR isolates, the 31-kD variant being phosphorylated most frequently. It was not phosphorylated in normal control B cells. PMID: 17701175
    16. Median survival time of cytoplasmic CD79 alpha positive group was shorter than that of cytCD79a negative group in acute myeloid leukemia. PMID: 18160827

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  • 相關(guān)疾?。?/div>
    Agammaglobulinemia 3, autosomal recessive (AGM3)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    B-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1698

    OMIM: 112205

    KEGG: hsa:973

    STRING: 9606.ENSP00000221972

    UniGene: Hs.631567



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