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  4. CD52 (Alemtuzumab Biosimilar) Recombinant Monoclonal Antibody

CD52 (Alemtuzumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA004943MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD52（Alemtuzumab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)CD52抗原的生物制劑，主要用于生命科學(xué)研究領(lǐng)域。CD52抗原廣泛表達(dá)于成熟淋巴細(xì)胞表面，包括T細(xì)胞、B細(xì)胞及自然殺傷細(xì)胞等，這一特性使得該抗體在免疫系統(tǒng)相關(guān)研究中具有重要應(yīng)用價(jià)值。 該抗體通過基因工程技術(shù)制備，具有高特異性和親和力，能夠精準(zhǔn)識(shí)別并結(jié)合CD52抗原，從而介導(dǎo)抗體依賴的細(xì)胞毒性（ADCC）或補(bǔ)體依賴的細(xì)胞毒性（CDC）效應(yīng)，誘導(dǎo)靶細(xì)胞凋亡。在科研實(shí)驗(yàn)中，它可用于淋巴細(xì)胞的分離純化、免疫表型分析、細(xì)胞功能研究等，為探索免疫調(diào)節(jié)機(jī)制、自身免疫性疾病發(fā)病機(jī)制及淋巴瘤等血液系統(tǒng)疾病的病理研究提供有力工具。 此外，該抗體在免疫治療相關(guān)的基礎(chǔ)研究中也發(fā)揮重要作用，例如通過特異性清除淋巴細(xì)胞，建立免疫缺陷動(dòng)物模型，或用于評(píng)估新型免疫療法的靶向性和有效性。其重組表達(dá)工藝確保了批次間的穩(wěn)定性和一致性，為實(shí)驗(yàn)結(jié)果的可靠性提供保障。 作為科研用試劑，該產(chǎn)品僅用于體外研究，不適合臨床治療用途。研究人員可根據(jù)具體實(shí)驗(yàn)需求，將其應(yīng)用于細(xì)胞殺傷實(shí)驗(yàn)等多種技術(shù)平臺(tái)，助力深入揭示免疫系統(tǒng)的復(fù)雜調(diào)控網(wǎng)絡(luò)及相關(guān)疾病的分子機(jī)制。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Alemtuzumab research-grade biosimilar; Alemtuzumab (Genetical Recombination) research-grade biosimilar; Alemtuzumab (genetical recombination) (JAN) research-grade biosimilar; Alemtuzumab (USAN/INN) research-grade biosimilar; Anti-CD52 monoclonal antibody research-grade biosimilar; CA 1H-01 research-grade biosimilar; Campath research-grade biosimilar; CAMPATH-1H research-grade biosimilar; CLLS52 research-grade biosimilar; GZ-402673 research-grade biosimilar; LDP-03 research-grade biosimilar; Lemtrada research-grade biosimilar; MabCampath research-grade biosimilar; MabKampat research-grade biosimilar; Remniq research-grade biosimilar ;CD52 antibody; CDW52 antibody; HE5 antibody; CAMPATH-1 antigen antibody; CDw52 antibody; Cambridge pathology 1 antigen antibody; Epididymal secretory protein E5 antibody; Human epididymis-specific protein 5 antibody; He5 antibody; CD antigen CD52 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD52 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
  • 基因功能參考文獻(xiàn)：
    1. soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. PMID: 29997173
    2. CD52 is a novel prognostic NSC marker and a potential NSC target in a subset of patients with MDS and AML, which may have clinical implications and may explain clinical effects produced by alemtuzumab in these patients. PMID: 24799522
    3. carbohydrate moiety of sperm protein interferes with the complement system via binding to C1q PMID: 22386526
    4. CT60 single-nucleotide polymorphism of CTLA4 is a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia PMID: 21552305
    5. Clonal large granular lymphocytes exhibited decreased CD52 expression post-therapy in patients refractory to treatment. PMID: 19794084
    6. Our bioinformatics findings suggest that CD52 polymorphism may affect the efficiency of GPI anchor formation and thus may indirectly alter the response to anti-CD52 agents like alemtuzumabin renal transplantation. PMID: 20349607
    7. Review article on CD52 structure and function. PMID: 11860230
    8. HE5(CD52) mRNA and protein, expressed in epithelial cells of the distal epididymis, were not affected by the obstruction of the vas deferens. PMID: 14662784
    9. The relationship between this differential insertion and differences in glycosylation of rat and human CD52 is discussed. PMID: 16266689
    10. CD52 is widely expressed on human mast cells (MCs) and Waldenstrom's Macroglobulinemia bone marrow lymphoplasmacytic cells and provide the preclinical rationale for the use of alemtuzumab in the treatment of WM and possibly other MC-related disorders. PMID: 16796779
    11. In this study, we identified the antigen of 4C8 mAb as CD52. CD52 is a costimulatory molecule for induction of CD4-positive T cells. PMID: 16797237
    12. In contrast with CLL, the variable expression of CD52 among other hematologic malignancies suggests that target validation on a case-by-case basis will likely be necessary to guide the rational analysis of CAMPATH therapy. PMID: 17145843
    13. Our data demonstrate differences in the intensity of the CD52 antigen expression between B-lymphocytes and tumor lymphocytes of B-CLL patients, and between B-CLL and SLL tumor cells. CD52 antigen is expressed at low level on CD34(+) cells. PMID: 17428002
    14. The semenogelin-CD52 soluble form is a direct consequence of the liquefaction process in human semen. PMID: 17624925
    15. We first showed the expression of CD52 in human cumulus cells. CD52 has some functional roles around fertilization in females as well as in males. PMID: 18647288
    16. A review on CD52 expression and function PMID: 11257744

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1804

    OMIM: 114280

    KEGG: hsa:1043

    STRING: 9606.ENSP00000363330

    UniGene: Hs.276770



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