日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 科研級(jí)生物類似抗體
  4. CD52 (ALLO-647 Biosimilar) Recombinant Monoclonal Antibody

CD52 (ALLO-647 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA004943MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD52 (ALLO-647 Biosimilar Antibody)重組單克隆抗體是一種針對(duì) CD52 抗原的生物工程蛋白，專為科研用途設(shè)計(jì)。CD52 是一種廣泛表達(dá)于淋巴細(xì)胞、單核細(xì)胞及部分生殖細(xì)胞表面的糖蛋白，其在免疫調(diào)控、細(xì)胞識(shí)別及信號(hào)轉(zhuǎn)導(dǎo)中發(fā)揮重要作用。該抗體通過(guò)基因工程技術(shù)重組表達(dá)，具有高特異性和親和力，可特異性識(shí)別并結(jié)合 CD52 抗原，為相關(guān)機(jī)制研究提供可靠工具。 在科研應(yīng)用中，CD52 (ALLO-647 Biosimilar Antibody)重組單克隆抗體可用于某些實(shí)驗(yàn)，助力分析 CD52 在不同細(xì)胞亞群中的表達(dá)特征，探討其在免疫疾病、腫瘤發(fā)生及生殖生物學(xué)等領(lǐng)域的作用機(jī)制。通過(guò)靶向結(jié)合 CD52，該抗體可用于研究其在細(xì)胞凋亡、免疫細(xì)胞活化與增殖中的調(diào)控功能，為開(kāi)發(fā)基于 CD52 靶點(diǎn)的治療策略提供實(shí)驗(yàn)依據(jù)。 該產(chǎn)品采用重組表達(dá)系統(tǒng)制備，確保批次間的穩(wěn)定性和一致性，適用于各類基礎(chǔ)研究和藥物研發(fā)前期的機(jī)制驗(yàn)證。其高純度和低交叉反應(yīng)性可有效減少實(shí)驗(yàn)干擾，提高研究數(shù)據(jù)的可靠性。作為科研工具，CD52 (ALLO-647 Biosimilar Antibody)重組單克隆抗體為深入探索 CD52 相關(guān)生物學(xué)過(guò)程及疾病機(jī)制提供了關(guān)鍵支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ALLO647 research-grade biosimilar; ALLO 647 research-grade biosimilar; Anti-CD52 monoclonal antibody research-grade biosimilar ;CD52 antibody; CDW52 antibody; HE5 antibody; CAMPATH-1 antigen antibody; CDw52 antibody; Cambridge pathology 1 antigen antibody; Epididymal secretory protein E5 antibody; Human epididymis-specific protein 5 antibody; He5 antibody; CD antigen CD52 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD52 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
  • 基因功能參考文獻(xiàn)：
    1. soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. PMID: 29997173
    2. CD52 is a novel prognostic NSC marker and a potential NSC target in a subset of patients with MDS and AML, which may have clinical implications and may explain clinical effects produced by alemtuzumab in these patients. PMID: 24799522
    3. carbohydrate moiety of sperm protein interferes with the complement system via binding to C1q PMID: 22386526
    4. CT60 single-nucleotide polymorphism of CTLA4 is a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia PMID: 21552305
    5. Clonal large granular lymphocytes exhibited decreased CD52 expression post-therapy in patients refractory to treatment. PMID: 19794084
    6. Our bioinformatics findings suggest that CD52 polymorphism may affect the efficiency of GPI anchor formation and thus may indirectly alter the response to anti-CD52 agents like alemtuzumabin renal transplantation. PMID: 20349607
    7. Review article on CD52 structure and function. PMID: 11860230
    8. HE5(CD52) mRNA and protein, expressed in epithelial cells of the distal epididymis, were not affected by the obstruction of the vas deferens. PMID: 14662784
    9. The relationship between this differential insertion and differences in glycosylation of rat and human CD52 is discussed. PMID: 16266689
    10. CD52 is widely expressed on human mast cells (MCs) and Waldenstrom's Macroglobulinemia bone marrow lymphoplasmacytic cells and provide the preclinical rationale for the use of alemtuzumab in the treatment of WM and possibly other MC-related disorders. PMID: 16796779
    11. In this study, we identified the antigen of 4C8 mAb as CD52. CD52 is a costimulatory molecule for induction of CD4-positive T cells. PMID: 16797237
    12. In contrast with CLL, the variable expression of CD52 among other hematologic malignancies suggests that target validation on a case-by-case basis will likely be necessary to guide the rational analysis of CAMPATH therapy. PMID: 17145843
    13. Our data demonstrate differences in the intensity of the CD52 antigen expression between B-lymphocytes and tumor lymphocytes of B-CLL patients, and between B-CLL and SLL tumor cells. CD52 antigen is expressed at low level on CD34(+) cells. PMID: 17428002
    14. The semenogelin-CD52 soluble form is a direct consequence of the liquefaction process in human semen. PMID: 17624925
    15. We first showed the expression of CD52 in human cumulus cells. CD52 has some functional roles around fertilization in females as well as in males. PMID: 18647288
    16. A review on CD52 expression and function PMID: 11257744

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1804

    OMIM: 114280

    KEGG: hsa:1043

    STRING: 9606.ENSP00000363330

    UniGene: Hs.276770



×
生命科學(xué)計(jì)算平臺(tái)