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  4. CD37 (ivicentamab Biosimilar) Recombinant Monoclonal Antibody

CD37 (ivicentamab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004928MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    CD37 (ivicentamab Biosimilar Antibody) 重組單克隆抗體是一種針對CD37抗原，其別名為CD 37抗體、CD37 antigen antibody、Tetraspanin-26 antibody等，對應靶標包括CD37分子、白細胞表面抗原CD37及TSPAN26等。該抗體以重組人CD37蛋白制備，具有高度的人源種屬反應性，專門識別并結合人類CD37抗原。 ivicentamab Biosimilar Antibody作為靶向CD37抗體，ivicentamab的類似物，其作用機制是通過特異性結合CD37，可能誘導抗體依賴的細胞介導的細胞毒性（ADCC）、補體依賴的細胞毒性（CDC）或直接抑制腫瘤細胞增殖，目前研究聚焦于其在復發(fā)/難治性B細胞淋巴瘤中的單藥或聯(lián)合治療潛力，旨在為患者提供更可及的靶向治療選擇。 該抗體可用于多種實驗場景：通過技術檢測CD37在細胞系或組織樣本中的表達水平；借助分析B細胞亞群的CD37表達差異；或在體外細胞模型及動物模型中探究CD37在B細胞發(fā)育、信號轉導及腫瘤發(fā)生中的分子機制。其高特異性和人源反應性確保了實驗結果的可靠性，為CD37相關基礎研究及藥物開發(fā)提供關鍵工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD 37 antibody; CD37 antibody; CD37 antigen antibody; CD37 molecule antibody; CD37_HUMAN antibody; Cell differentiation antigen 37 antibody; GP52 40 antibody; Leukocyte antigen CD37 antibody; Leukocyte surface antigen CD37 antibody; MGC120234 antibody; Tetraspanin 26 antibody; Tetraspanin-26 antibody; Tetraspanin26 antibody; TSPAN 26 antibody; Tspan-26 antibody; TSPAN26 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CD37 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
    2. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
    3. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
    4. Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
    5. Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
    6. In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
    7. CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
    8. CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
    9. provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 組織特異性：
    B-lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1666

    OMIM: 151523

    KEGG: hsa:951

    STRING: 9606.ENSP00000325708

    UniGene: Hs.166556



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