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  4. CCR8 (US20220064312A1 Biosimilar) Recombinant Monoclonal Antibody

CCR8 (US20220064312A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004847MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CCR8 (US20220064312A1 Biosimilar Antibody) 重組單克隆抗體是一種針對C-C趨化因子受體8（CCR8），其靶點CCR8存在多個別名，包括C-C CKR-8、CC-CKR-8、CCR-8、CC趨化因子受體CHEMR1、CMKBRL2、趨化因子受體樣1、CKR-L1、GPR-CY6、GPRCY6、TER1以及CD抗原CDw198等。該抗體以重組人CCR8蛋白制備，具有高度的種屬反應(yīng)性，主要針對人源CCR8分子。 針對靶向CCR8抗體，US20220064312A1的類似物作為一種靶向治療手段，其作用機(jī)制與調(diào)節(jié)免疫細(xì)胞募集和活化相關(guān)，尤其在腫瘤微環(huán)境中，CCR8+調(diào)節(jié)性T細(xì)胞（Treg）的富集與免疫抑制及腫瘤進(jìn)展密切相關(guān)。因此，此類藥物被開發(fā)用于特異性清除腫瘤微環(huán)境中的CCR8+ Treg細(xì)胞，解除免疫抑制，增強(qiáng)抗腫瘤免疫應(yīng)答。目前，相關(guān)臨床應(yīng)用研究聚焦于實體瘤治療，如乳腺癌、肺癌等，通過單藥或聯(lián)合免疫檢查點抑制劑，探索其在改善患者預(yù)后、提高治療響應(yīng)率方面的潛力。 該抗體為CCR8生物學(xué)功能研究提供了重要工具。研究者可利用其特異性結(jié)合特性，開展受體定位、信號通路分析及免疫細(xì)胞亞群鑒定實驗。例如，通過檢測CCR8在免疫細(xì)胞中的表達(dá)水平，或采用方法觀察其在腫瘤組織中的分布，助力深入解析CCR8在免疫調(diào)節(jié)、炎癥反應(yīng)及腫瘤發(fā)生發(fā)展中的機(jī)制，為開發(fā)新型靶向治療策略奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C-C chemokine receptor type 8；C-C CKR-8；CC-CKR-8；CCR-8；CC chemokine receptor CHEMR1；CMKBRL2；Chemokine receptor-like 1；CKR-L1；GPR-CY6；GPRCY6；TER1；CD antigen CDw198, CCR8, CKRL1 CMKBR8 CMKBRL2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CCR8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
  • 基因功能參考文獻(xiàn)：
    1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
    2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
    3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
    6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
    7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
    8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
    9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
    10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
    12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
    13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
    14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
    15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
    16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
    17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
    18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
    19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
    20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
    21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
    22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1609

    OMIM: 601834

    KEGG: hsa:1237

    STRING: 9606.ENSP00000326432

    UniGene: Hs.113222



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