CCR8 (Lanerkitug Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA004847MB10HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:CCR8(Lanerkitug Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物制劑,其研發(fā)旨在為相關研究提供特異性靶向工具。該抗體以趨化因子受體8(CCR8)為作用靶點,通過基因工程技術重組表達制備而成,具有高親和力和特異性結(jié)合能力。 在免疫學和腫瘤學研究中,CCR8作為G蛋白偶聯(lián)受體家族成員,在調(diào)節(jié)免疫細胞遷移、腫瘤微環(huán)境重塑等生理病理過程中發(fā)揮重要作用。本產(chǎn)品可應用于多種實驗場景,包括但不限于以及體外細胞功能實驗等,助力科研人員深入探究CCR8的分子機制及其在疾病發(fā)生發(fā)展中的作用。 該重組單克隆抗體制備過程嚴格遵循標準化流程,通過抗體可變區(qū)基因克隆、表達載體構(gòu)建、哺乳動物細胞表達及多步純化工藝,確保產(chǎn)品具有高純度和批次間穩(wěn)定性。其生物學活性經(jīng)嚴格驗證,可特異性識別并結(jié)合CCR8,有效避免與其他趨化因子受體的交叉反應,為實驗結(jié)果的可靠性提供有力保障。 作為科研用工具試劑,本產(chǎn)品為揭示CCR8相關信號通路、開發(fā)靶向治療策略等研究方向提供了關鍵支持,適用于高校實驗室、科研院所及生物醫(yī)藥企業(yè)的基礎研究與應用研究項目。使用時需按照實驗方案要求進行稀釋和操作,具體應用范圍可根據(jù)研究需求進一步拓展。
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Uniprot No.:
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基因名:
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別名:BAY 3375968 research-grade biosimilar; BAY-3375968 research-grade biosimilar ;CCR8 antibody; CKRL1 antibody; CMKBR8 antibody; CMKBRL2 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC-CKR-8 antibody; CCR-8 antibody; CC chemokine receptor CHEMR1 antibody; CMKBRL2 antibody; Chemokine receptor-like 1 antibody; CKR-L1 antibody; GPR-CY6 antibody; GPRCY6 antibody; TER1 antibody; CD antigen CDw198 antibody
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反應種屬:Human
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免疫原:Recombinant Human CCR8 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產(chǎn)品
靶點詳情
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功能:Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
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基因功能參考文獻:
- Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
- Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
- High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
- findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
- Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
- CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
- Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
- CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
- Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
- C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
- The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
- There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
- CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
- found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
- CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
- Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
- The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
- the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
- CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
- CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
- CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
- The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family
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