CCR8 (HBM-1022 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA004847MB9HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:CCR8(HBM-1022 Biosimilar Antibody)重組單克隆抗體是一種專為科研應(yīng)用開發(fā)的生物試劑,其核心成分為針對趨化因子受體8(CCR8)的重組單克隆抗體。該產(chǎn)品通過先進的基因工程技術(shù)制備,具有高特異性和高親和力,可精準識別并結(jié)合CCR8分子,為相關(guān)研究提供可靠的工具支持。 CCR8作為G蛋白偶聯(lián)受體家族成員,在免疫調(diào)節(jié)、炎癥反應(yīng)及腫瘤微環(huán)境等領(lǐng)域的研究中具有重要意義。本產(chǎn)品可廣泛應(yīng)用于多種實驗場景,包括但不限于細胞流式分析檢測。通過特異性結(jié)合CCR8,能夠助力研究人員深入探索其在生理及病理過程中的功能機制,如免疫細胞遷移、信號通路調(diào)控等。 該抗體采用重組表達系統(tǒng)生產(chǎn),嚴格控制生產(chǎn)過程中的各項參數(shù),確保產(chǎn)品批次間的穩(wěn)定性和一致性。其高純度的特性可有效降低非特異性結(jié)合帶來的實驗干擾,提升實驗結(jié)果的可靠性。同時,產(chǎn)品經(jīng)過嚴格的質(zhì)量驗證,包括效價測定、純度分析及活性檢測等,以滿足科研實驗對試劑品質(zhì)的高要求。 在科研應(yīng)用中,CCR8重組單克隆抗體為揭示相關(guān)疾病的分子機制、開發(fā)潛在治療靶點提供了有力支持。無論是基礎(chǔ)研究還是藥物研發(fā)前期的靶點驗證,本產(chǎn)品均能發(fā)揮重要作用,幫助研究人員高效推進科研項目進展,為生命科學領(lǐng)域的探索提供關(guān)鍵工具。
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Uniprot No.:
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基因名:
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別名:Anti CCR8 monoclonal antibody - Harbour BioMed research-grade biosimilar; HBM1022 research-grade biosimilar; HBM 1022 research-grade biosimilar ;CCR8 antibody; CKRL1 antibody; CMKBR8 antibody; CMKBRL2 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC-CKR-8 antibody; CCR-8 antibody; CC chemokine receptor CHEMR1 antibody; CMKBRL2 antibody; Chemokine receptor-like 1 antibody; CKR-L1 antibody; GPR-CY6 antibody; GPRCY6 antibody; TER1 antibody; CD antigen CDw198 antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human CCR8 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
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基因功能參考文獻:
- Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
- Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
- High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
- findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
- Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
- CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
- Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
- CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
- Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
- C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
- The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
- There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
- CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
- found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
- CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
- Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
- The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
- the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
- CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
- CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
- CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
- The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family
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