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  4. CCL24 (Nebokitug Biosimilar) Recombinant Monoclonal Antibody

CCL24 (Nebokitug Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004788MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CCL24(Nebokitug Biosimilar Antibody)重組單克隆抗體是一種針對CCL24（即嗜酸性粒細(xì)胞趨化因子3，Eotaxin-3）的重組單克隆抗體，專為科研實(shí)驗(yàn)設(shè)計(jì)開發(fā)。該產(chǎn)品通過基因工程技術(shù)在哺乳動(dòng)物細(xì)胞中表達(dá)，具有高純度、高特異性和良好的生物學(xué)活性，為炎癥性疾病、免疫調(diào)控及相關(guān)信號通路研究提供可靠工具。 作為趨化因子家族成員，CCL24在嗜酸性粒細(xì)胞招募、過敏性炎癥及組織纖維化進(jìn)程中發(fā)揮關(guān)鍵作用。本抗體可特異性識別并結(jié)合CCL24，通過中和其生物學(xué)活性或標(biāo)記定位，助力研究人員深入探究其在哮喘、特應(yīng)性皮炎、鼻息肉等疾病模型中的病理機(jī)制。產(chǎn)品經(jīng)嚴(yán)格質(zhì)量控制，通過SDS-PAGE、HPLC等方法驗(yàn)證純度，ELISA及細(xì)胞結(jié)合實(shí)驗(yàn)確保結(jié)合活性，可滿足及體外中和實(shí)驗(yàn)等多種科研需求。 該抗體適用于免疫檢測、蛋白質(zhì)相互作用分析及體內(nèi)外功能研究，為闡明CCL24介導(dǎo)的炎癥信號網(wǎng)絡(luò)提供有力支持。推薦儲存于-20℃，避免反復(fù)凍融，使用前需根據(jù)實(shí)驗(yàn)需求進(jìn)行稀釋。其高度的靶向性和批次穩(wěn)定性，使其成為免疫學(xué)、細(xì)胞生物學(xué)及轉(zhuǎn)化醫(yī)學(xué)研究領(lǐng)域的理想實(shí)驗(yàn)試劑，助力推動(dòng)相關(guān)疾病機(jī)制的基礎(chǔ)研究與潛在治療靶點(diǎn)的探索。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CM101 research-grade biosimilar; CM101 (Chemomab) research-grade biosimilar; CM 101 (Chemomab) research-grade biosimilar ;CCL24 antibody; MPIF2 antibody; SCYA24 antibody; C-C motif chemokine 24 antibody; CK-beta-6 antibody; Eosinophil chemotactic protein 2 antibody; Eotaxin-2 antibody; Myeloid progenitor inhibitory factor 2 antibody; MPIF-2 antibody; Small-inducible cytokine A24 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CCL24 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.
  • 基因功能參考文獻(xiàn)：
    1. Study showed that CCL24 was upregulated in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis in HCC patients . Also, CCL24 was associated with the metastatic potential of HCC cell lines and promoted proliferation, migration, and invasion. PMID: 28042950
    2. Mean eotaxin 2 concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects. PMID: 28587510
    3. HMGB1 did not elicit chemotaxis of human eosinophils alone and had no effect in combination with the eosinophil chemotactic agent, eotaxin-2 (CCL24). PMID: 25774667
    4. these data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family. PMID: 24989688
    5. Pregnancy associated environments increased local CCL24/CCR3, supporting the process of decidualization in human early pregnancy. PMID: 23696919
    6. Phosphodiesterase 4 inhibitors, rolipram and RO-20-1724 have no effect on CCL24 expression in human primary bronchial epithelial cells. PMID: 22946025
    7. Study shows that CCL24 levels were significantly increased in age-related macular degeneration (AMD) patients despite Avastin treatment as compared with normal controls and those without Avastin. PMID: 23025269
    8. CCR3 is differentially expressed on inflammatory cells in rheumatoid arthritis, while eotaxin-2, a potent CCR3 agonist, is differentially expressed in active disease. PMID: 20659406
    9. stimulates lung fibroblast proliferation and collagen synthesis PMID: 20143648
    10. alters eosinophil integrin function via mitogen-activated protein kinases PMID: 12034562
    11. Intradermal injection of CCL24 induces recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions in atopic and nonatopic volunteers. PMID: 12193745
    12. Plasma eotaxin-2 concentrations differed in asthmatic patients with respect to aspirin intolerance and tolerance, indicating that eotaxin-2 may be differentially up-regulated according to aspirin intolerance. PMID: 16304252
    13. Our results suggest that Eo2 +179T>C and Eo2 +275C>T of eotaxin-2 might be associated with the susceptibility of ulcerative colitis. PMID: 16391516
    14. These data support the idea that CCL24/eotaxin-2 is part of the mechanism of CD4 lymphocyte activation paracrinally induced by Nef. PMID: 17630924
    15. eotaxin-2 is a chemokine strongly associated with primary and metastatic tumors of colorectal origin PMID: 17908961
    16. the ability to produce eotaxin-2/CCL24 is acquired during the differentiation into eosinophilic lineage which is dependent on GATA-1 expression PMID: 17917245
    17. This protein is an eosinophil chemoattractant that is up-regulated by human rhinovirus infection in cultured bronchial epithelial cells. PMID: 11467997

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Activated monocytes and activated T lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10623

    OMIM: 602495

    KEGG: hsa:6369

    STRING: 9606.ENSP00000222902

    UniGene: Hs.247838



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