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  4. C2 (Empasiprubart Biosimilar) Recombinant Monoclonal Antibody

C2 (Empasiprubart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA003658MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    C2 (Empasiprubart Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物制劑。該產(chǎn)品通過重組DNA技術制備，具有高度均一性和特異性，為生命科學研究提供了可靠的工具。 作為單克隆抗體，C2 (Empasiprubart) 能夠特異性識別并結(jié)合靶分子，在生物學研究中可廣泛應用于蛋白檢測某些實驗。其精確的靶向結(jié)合能力有助于研究人員深入探索生物分子的功能、信號通路及疾病機制。 該重組單克隆抗體制備過程嚴格遵循質(zhì)量控制標準，確保產(chǎn)品的高純度和批次間的一致性。通過優(yōu)化的表達系統(tǒng)和純化工藝，有效保障了抗體的生物學活性和結(jié)構穩(wěn)定性，為科研實驗結(jié)果的可靠性提供了有力支持。 在科研應用中，C2 (Empasiprubart Biosimilar Antibody)重組單克隆抗體可作為關鍵試劑，助力于疾病相關靶點的驗證、藥物作用機制研究以及生物標志物的發(fā)現(xiàn)等前沿科學探索。其特異性結(jié)合特性使其成為研究蛋白質(zhì)相互作用、細胞信號傳導以及疾病模型構建等領域的重要工具，為生命科學研究的深入開展提供了技術支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ARGX 117 research-grade biosimilar; ARGX-117 research-grade biosimilar; empasiprubart research-grade biosimilar ;C2 antibody; Complement C2 antibody; C3/C5 convertase [Cleaved into: Complement C2a antibody; Serine protease complement C2b antibody; EC 3.4.21.43] antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human C2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
  • 基因功能參考文獻：
    1. Vag8 binding to human C1-inhibitor (C1-inh) interferes with the binding of C1-inh to C1s, C1r and MASP-2, resulting in the release of active proteases that subsequently cleave C2 and C4 away from the bacterial surface. PMID: 28742139
    2. Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases. PMID: 27252379
    3. The rs2844455 A allele of C2 is a risk factor for systemic lupus erythematosus development in a Chinese population, whereas the G allele might be a protective factor. PMID: 26176736
    4. our data indicate that C2 rs547154 polymorphism plays a protective role in the development of PCV. PMID: 25732348
    5. Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. PMID: 24983375
    6. These overall results suggest a lack of strong association with the C2 and C7 gene polymorphisms to the susceptibility of systemic lupus erythematosus in the Malaysian population. PMID: 21881993
    7. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
    8. CFH (RS1061170), C2 (RS547154), OR CFB (RS438999) was not associated with early or late AMD. PMID: 23060141
    9. These data suggest that patients with C2 deficiency are at increased risk of Streptococcus pyogenes infections. PMID: 20417301
    10. C2 microheterogeneity and histocompatibility antigens Class I were studied in an Austrian population. PMID: 12823772
    11. study of the formation of high affinity C5 convertase of the classical pathway of complement PMID: 12878586
    12. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 PMID: 16670774
    13. a weaker, independent protective effect exists for complement component 2 in age related macular degeneration. PMID: 17576744
    14. These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections. PMID: 18541650
    15. Study provides insights into the genetic pathogenesis of AMD, and C2 has been shown as one of the five genes independently involved in progression from intermediate disease to advanced disease in which blindness is frequent. PMID: 19015224
    16. Upon cleavage by C1s, C2a domains undergo conformational rotation while bound to C4b and the released C2b domains may remain folded together as seen in the intact protein. PMID: 19237749

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  • 相關疾病：
    Complement component 2 deficiency (C2D)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1248

    OMIM: 217000

    KEGG: hsa:717

    STRING: 9606.ENSP00000299367

    UniGene: Hs.408903



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