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  4. C1S (riliprubart Biosimilar) Recombinant Monoclonal Antibody

C1S (riliprubart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA003657MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    C1S (riliprubart Biosimilar Antibody) 重組單克隆抗體，其別名包括Basic proline rich peptide IB 1 antibody、C1 esterase antibody、C1S_HUMAN antibody、Complement C1s subcomponent antibody等，主要針對補(bǔ)體系統(tǒng)中的C1s亞組分。該抗體以重組人C1S蛋白制備而成，具有高度的種屬反應(yīng)性，專門識(shí)別人源C1S蛋白。 riliprubart作為針對C1s亞組分的生物類似藥抗體，其作用機(jī)制是特異性抑制C1s活性，阻斷補(bǔ)體級聯(lián)反應(yīng)的過度激活，從而減輕組織損傷和炎癥反應(yīng)。目前，該抗體研發(fā)的藥物的臨床應(yīng)用研究聚焦于系統(tǒng)性紅斑狼瘡、類風(fēng)濕關(guān)節(jié)炎、膜性腎病等補(bǔ)體介導(dǎo)疾病，旨在評估其在這些疾病治療中的安全性、藥代動(dòng)力學(xué)特征及治療效果，相關(guān)臨床試驗(yàn)正處于探索階段。 C1S重組單克隆抗體是研究補(bǔ)體系統(tǒng)功能與調(diào)控機(jī)制的重要工具。通過特異性識(shí)別和結(jié)合C1S蛋白，可用于免疫沉淀實(shí)驗(yàn)，助力研究者在分子水平解析C1S的表達(dá)模式、相互作用蛋白及信號通路。此外，該抗體還可用于構(gòu)建補(bǔ)體激活相關(guān)的細(xì)胞模型和動(dòng)物模型，為深入探究補(bǔ)體系統(tǒng)在疾病發(fā)生發(fā)展中的作用提供支持，為開發(fā)新型補(bǔ)體靶向療法奠定基礎(chǔ)。 總之，C1S (riliprubart Biosimilar Antibody) 重組單克隆抗體憑借其特異性和人源反應(yīng)性，在補(bǔ)體相關(guān)疾病的臨床轉(zhuǎn)化研究和基礎(chǔ)科研中展現(xiàn)出重要價(jià)值，為理解補(bǔ)體系統(tǒng)功能及開發(fā)創(chuàng)新治療策略提供了有力工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Basic proline rich peptide IB 1 antibody; C1 esterase antibody; C1S antibody; C1S_HUMAN antibody; Complement C1s subcomponent antibody; Complement C1s subcomponent heavy chain antibody; Complement C1s subcomponent light chain antibody; Complement component 1 s subcomponent antibody; Complement component 1 subcomponent s antibody; FLJ44757 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human C1S protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
  • 基因功能參考文獻(xiàn)：
    1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
    2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
    3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
    4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
    5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
    7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
    8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908

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  • 相關(guān)疾病：
    Complement component C1s deficiency (C1SD); Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2)
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1247

    OMIM: 120580

    KEGG: hsa:716

    STRING: 9606.ENSP00000328173

    UniGene: Hs.458355



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