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  4. C1S (Sutimlimab Biosimilar) Recombinant Monoclonal Antibody

C1S (Sutimlimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA003657MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    C1S (Sutimlimab Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑，其研發(fā)旨在為補(bǔ)體系統(tǒng)相關(guān)機(jī)制的研究提供工具。該抗體以重組DNA技術(shù)制備，靶向補(bǔ)體系統(tǒng)中的關(guān)鍵組分C1s蛋白酶，通過(guò)特異性結(jié)合抑制其活性，從而調(diào)控補(bǔ)體經(jīng)典途徑的激活過(guò)程。 在科研應(yīng)用中，該抗體可用于探究補(bǔ)體系統(tǒng)在自身免疫性疾病、炎癥反應(yīng)及免疫調(diào)節(jié)中的作用機(jī)制。通過(guò)精準(zhǔn)阻斷C1s介導(dǎo)的補(bǔ)體級(jí)聯(lián)反應(yīng)，研究人員能夠在細(xì)胞模型或動(dòng)物模型中分析補(bǔ)體過(guò)度激活與疾病發(fā)生的關(guān)聯(lián)，為闡明相關(guān)疾病的病理生理過(guò)程提供實(shí)驗(yàn)支持。 該抗體具有高特異性和親和力，能夠與C1s蛋白形成穩(wěn)定復(fù)合物，有效抑制其對(duì)C4和C2的切割活性，進(jìn)而阻止補(bǔ)體系統(tǒng)下游的C3轉(zhuǎn)化酶形成及后續(xù)的炎癥介質(zhì)釋放。其重組表達(dá)體系確保了批次間的一致性和高純度，適合在分子生物學(xué)、細(xì)胞生物學(xué)及動(dòng)物實(shí)驗(yàn)中作為特異性干預(yù)工具使用。 作為科研用試劑，該抗體為補(bǔ)體系統(tǒng)功能研究、潛在治療靶點(diǎn)驗(yàn)證及相關(guān)藥物開(kāi)發(fā)提供了重要實(shí)驗(yàn)材料，助力深入探索補(bǔ)體調(diào)控在疾病治療中的應(yīng)用前景。研究人員可通過(guò)結(jié)合該抗體的特異性抑制效應(yīng)，開(kāi)展機(jī)制驗(yàn)證、信號(hào)通路分析及藥效評(píng)估某些實(shí)驗(yàn)，推動(dòng)補(bǔ)體相關(guān)領(lǐng)域的基礎(chǔ)研究與轉(zhuǎn)化醫(yī)學(xué)進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C1s VH4V2 research-grade biosimilar; BIVV009 research-grade biosimilar; BIVV-009 research-grade biosimilar; Enjaymo research-grade biosimilar; Sutimlimab research-grade biosimilar; Sutimlimab (genetical recombination) (JAN) research-grade biosimilar; Sutimlimab (USAN/INN) research-grade biosimilar; sutimlimab-jome research-grade biosimilar; TNT009 research-grade biosimilar; TNT-009 research-grade biosimilar ;C1S antibody; Complement C1s subcomponent antibody; EC 3.4.21.42 antibody; C1 esterase antibody; Complement component 1 subcomponent s [Cleaved into: Complement C1s subcomponent heavy chain antibody; Complement C1s subcomponent chain A antibody; Complement C1s subcomponent light chain antibody; Complement C1s subcomponent chain B] antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human C1S protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
  • 基因功能參考文獻(xiàn)：
    1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
    2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
    3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
    4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
    5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
    7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
    8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908

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  • 相關(guān)疾病：
    Complement component C1s deficiency (C1SD); Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2)
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1247

    OMIM: 120580

    KEGG: hsa:716

    STRING: 9606.ENSP00000328173

    UniGene: Hs.458355



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