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  4. BTN3A1 (ICT-01 Biosimilar) Recombinant Monoclonal Antibody

BTN3A1 (ICT-01 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA002873MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    BTN3A1(ICT-01 Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物試劑，專(zhuān)為靶向BTN3A1蛋白設(shè)計(jì)。該抗體通過(guò)重組DNA技術(shù)制備，具有高特異性和親和力，可精準(zhǔn)識(shí)別并結(jié)合BTN3A1抗原表位，為相關(guān)研究提供可靠的分子工具。 BTN3A1蛋白屬于B7家族成員，在免疫調(diào)節(jié)、細(xì)胞活化及炎癥反應(yīng)中發(fā)揮重要作用。該抗體可用于多種實(shí)驗(yàn)場(chǎng)景，包括，助力研究人員分析BTN3A1在不同組織、細(xì)胞中的表達(dá)水平與定位特征，深入探討其生物學(xué)功能及相關(guān)信號(hào)通路機(jī)制。 產(chǎn)品采用嚴(yán)格的質(zhì)量控制流程，確?？贵w純度、活性及批次穩(wěn)定性，適用于基礎(chǔ)免疫學(xué)、腫瘤生物學(xué)、自身免疫性疾病等領(lǐng)域的機(jī)制研究。通過(guò)特異性阻斷或檢測(cè)BTN3A1蛋白，該抗體為揭示其在免疫應(yīng)答調(diào)控、疾病發(fā)生發(fā)展中的作用提供關(guān)鍵實(shí)驗(yàn)支持，是推動(dòng)相關(guān)科研進(jìn)展的重要工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Humanized anti-butyrophilin-3A (ImCheck) research-grade biosimilar; ICT 01 research-grade biosimilar; ICT-01 research-grade biosimilar; ICT01 - ImCheck Therapeutics research-grade biosimilar ;BTN3A1 antibody; BTF5 antibody; Butyrophilin subfamily 3 member A1 antibody; CD antigen CD277 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human BTN3A1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
  • 基因功能參考文獻(xiàn)：
    1. Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. PMID: 27911820
    2. results show that ligand binding to BTN3A1 induces a conformational change within the intracellular domain that involves the JM region and is required for full activation. PMID: 28705810
    3. findings show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced gammadelta T cell reactivity PMID: 28461569
    4. These findings support intracellular sensing of prenyl pyrophosphates by BTN3A1 rather than extracellular presentation. PMID: 26475929
    5. Human gamma-delta T cells are activated by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. PMID: 25637025
    6. evidence that gene(s) on Chr6 in addition to BTN3A1 are mandatory for PAg-mediated activation of Vgamma9Vdelta2 T cells. PMID: 24890657
    7. Ligand binding to the BTN3A1 B30.2 domain affects residues in the juxtamembrane region, suggesting ligand-induced conformational change. PMID: 25065532
    8. These studies demonstrate that internal sensing of changes in pAg metabolite concentrations by BTN3A1 molecules is a critical step in Vgamma9Vdelta2 T cell detection of infection and tumorigenesis. PMID: 24703779
    9. BTN3A1 represents an antigen-presenting molecule required for the activation of Vgamma9Vdelta2 T cells. PMID: 23872678
    10. investigation of role of CD277 in activation/inactivation of T-lymphocytes: Data indicate that modulation of CD277 interaction (with agonists or blocking antibodies) with T-cell antigen receptor can modulate activation/inactivation of T-lymphocytes. PMID: 22767497
    11. BTN3A1 is necessary for Vgamma9Vdelta2 activation and begin to unravel the extracellular events that occur during stimulation through the Vgamma9Vdelta2 T cell receptor. PMID: 22846996
    12. CD277 triggering is not involved in CD16- or NKp46-induced NK cell activation. PMID: 21918970
    13. Results point to a role for CD277 up-regulated by microenvironmental signals in the acquisition of a regulatory phenotype by ovarian tumor-associated myeloid cells. PMID: 21113407

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, BTN/MOG family
  • 組織特異性：
    Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1138

    OMIM: 613593

    KEGG: hsa:11119

    STRING: 9606.ENSP00000289361

    UniGene: Hs.191510



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