AREG (PMG-1015 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA001986MB1HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:AREG (PMG-1015 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物試劑,旨在為生命科學(xué)領(lǐng)域的研究提供精準的靶向工具。該產(chǎn)品通過重組DNA技術(shù)制備,具有高度的特異性和均一性,能夠特異性識別并結(jié)合AREG(Amphiregulin,雙調(diào)蛋白)分子,為相關(guān)機制研究、信號通路分析及疾病模型構(gòu)建等提供可靠支持。 作為單克隆抗體,AREG (PMG-1015) 具有單一抗原結(jié)合位點,可有效避免多克隆抗體批次間差異帶來的實驗誤差,確保研究結(jié)果的穩(wěn)定性和可重復(fù)性。其生產(chǎn)過程嚴格遵循標準化流程,通過先進的蛋白純化技術(shù)去除雜質(zhì),保證產(chǎn)品的高純度和低內(nèi)毒素水平,降低非特異性結(jié)合對實驗的干擾。 在科研應(yīng)用中,該抗體可廣泛用于、ELISA等多種實驗技術(shù),助力研究人員深入探索AREG在細胞增殖、分化、腫瘤發(fā)生發(fā)展、炎癥反應(yīng)等生理及病理過程中的作用機制。無論是基礎(chǔ)研究中的分子互作分析,還是藥物研發(fā)前期的靶點驗證,AREG (PMG-1015 Biosimilar Antibody)重組單克隆抗體均能憑借其優(yōu)異的性能為科研工作提供有力支持。 本產(chǎn)品僅用于實驗室研究,不用于臨床診斷或治療用途。使用時需按照相關(guān)實驗規(guī)范操作,并結(jié)合具體研究需求優(yōu)化實驗條件,以獲得最佳結(jié)果。
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Uniprot No.:
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基因名:
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別名:a humanized, immunoglobulin G subtype 4 anti-Amphiregulin monoclonal antibody research-grade biosimilar; PMG 1015 research-grade biosimilar; PMG-1015 research-grade biosimilar ;AREG antibody; AREGB antibody; SDGF antibody; Amphiregulin antibody; AR antibody; Colorectum cell-derived growth factor antibody; CRDGF antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human AREG protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
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基因功能參考文獻:
- Amphiregulin contained in non-small-cell lung carcinoma-derived exosomes induces osteoclast differentiation through the activation of EGFR pathway. PMID: 28600504
- The studies indicate that HIF2-alpha induces myocardial AREG expression in cardiac myocytes, which increases myocardial ischemia tolerance. PMID: 29483579
- AREG mediates hCG-induced StAR expression and progesterone production in human granulosa cells, providing novel evidence for the role of AREG in the regulation of steroidogenesis. PMID: 27113901
- Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function. PMID: 27040371
- No significant correlations emerged for YAP or AREG expression and VIII CN schwannoma volume. PMID: 28430338
- Cullin 3 regulates ADAM17-mediated ectodomain shedding of AREG. PMID: 29550478
- over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring. PMID: 27713123
- Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells. PMID: 27835572
- Results show that AREG expression is up-regulated in gastric tumor and its co-expression with TROP2 protein is associated with TNM stage, tumor size, lymph node metastases, and distant metastases. PMID: 28256068
- secretion of IL-13 and amphiregulin suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease. PMID: 29261670
- EGF-AREG interplay in airway basal cell stem/progenitor cells is one of the mechanisms that mediates the interconnected pathogenesis of all major smoking-induced lesions in the human airway epithelium. PMID: 27709733
- AREG expression may be useful for identifying CRTC1-MAML2-positive mucoepidermoid carcinomas and as a marker for favorable prognosis. PMID: 27393417
- Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCdelta pathway. PMID: 27826039
- Amphiregulin plays an important role in lung neoplasm resistance to amrubicinol PMID: 28476786
- EREG and AREG are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site. PMID: 27272216
- These findings demonstrate the posttranslational regulation of Foxp3 expression by AREG in cancer patients through AREG/EGFR/GSK-3beta signaling, which could lead to Foxp3 protein degradation in Treg cells and a potential therapeutic target for cancer treatment. PMID: 27432879
- blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis PMID: 28351301
- keratinocyte expression of hAREG elicits inflammatory epidermal hyperplasia PMID: 26519132
- Low AREG expression is associated with gastric cancer. PMID: 26884344
- RYR2, PTDSS1 and AREG are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease. PMID: 26742492
- High Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in osteosarcoma. PMID: 26503469
- results demonstrate that AREG controls G2/M progression and cytokinesis in keratinocytes via activation of a FoxM1-dependent transcriptional program, suggesting new avenues for treatment of epithelial cancer PMID: 26234682
- High expression of amphiregulin is associated with hepatocellular carcinoma. PMID: 26451607
- Findings show the involvement of amphiregulin and semaphorin-3A in the improvement of skin innervations and penetration of nerve fibers into the epidermis. PMID: 26201903
- Altered AREG expression induced by diverse luteinizing hormone receptor reactivity in granulosa cells may provide a useful marker for oocyte developmental competency PMID: 25911599
- Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway. PMID: 25825984
- Our findings implicate amphiregulin as a critical mediator of the estrogen response in ERalpha-positive breast cancer PMID: 26527289
- AR induces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in murine and human NASH, suggesting that AR antagonists may be clinically useful anti-fibrotics in NAFLD. PMID: 25744849
- Bradykinin (BK) stimulation of human airway smooth muscle cell increases amphiregulin secretion in a mechanism dependent on BK-induced COX-2 expression. PMID: 26047642
- The applied drugs showed remarkable suppression of mTOR expression, which might delay tumor progression. Interestingly, sorafenib and sunitinib increased AREG in HNSCC 11A and 14C PMID: 25862847
- Expression profiling demonstrated that AREG-activated EGFR regulates gene expression differently than EGF-activated EGFR PMID: 25454348
- This study shows that TGF-alpha uses common and divergent molecular mediators to regulate E-cadherin expression and cell invasion. PMID: 25869072
- AREG rs1615111, located in the AREG genomic region, can significantly define different prognostic cohorts in locally advanced GC PMID: 25203737
- AREG induces ovarian cancer cell invasion by down-regulating E-cadherin expression PMID: 25261255
- During high-pressure ventilation, Nrf2 becomes activated and induces AREG, leading to a positive feedback loop between Nrf2 and AREG, which involves the p38 MAPK and results in the expression of cytoprotective genes. PMID: 24921206
- AREG expression was significantly correlated with Edmondson stage and serum AFP level. PMID: 24860833
- AREG shedding occurs through a TNF-alpha-converting enzyme-dependent mechanism in diacetyl treated pulmonary epithelial cells. PMID: 24816162
- aberrantly activated AREG-EGFR signaling is required for CRTC1-MAML2-positive MEC cell growth and survival, suggesting that EGFR-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC. PMID: 23975434
- Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer. PMID: 23851501
- IL-1beta-induced amphiregulin release may be involved in the pathogenesis of rheumatoid arthritis. PMID: 24196392
- These findings provide mechanistic insight into the regulation of YAP and AREG by RASSF1A in human multistep hepatocarcinogenesis. PMID: 23594797
- Data suggest that AREG (amphiregulin), BTC (betacellulin), and EREG (epiregulin) induced prostaglandin E2 production by induction of COX-2 (prostaglandin-endoperoxide synthase 2) through MAP kinase signaling in granulosa cells. PMID: 24092824
- Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA. PMID: 23844004
- Promoter methylation of AREG is associated with glioblastoma. PMID: 23624749
- AREG plays pro-neoplastic roles in colorectal carcinogenesis PMID: 23263765
- EREG-AREG and NRG1, which are members of the epidermal growth factor (EGF) family, seem to modulate Behcet's disease susceptibility through main effects and gene-gene interactions PMID: 23625463
- we did not find a correlation between the presence of a K-ras mutation and the presence of Epiregulin and Amphiregulin in colon cancer tissue. PMID: 23885463
- Regulation of amphiregulin gene expression by beta-catenin signaling in human hepatocellular carcinoma cells. PMID: 23285165
- Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. PMID: 23430747
- Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling, which has implications in ADPKD cell proliferation PMID: 22570239
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亞細胞定位:Membrane; Single-pass membrane protein.
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蛋白家族:Amphiregulin family
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