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  4. APCS (dezamizumab Biosimilar) Recombinant Monoclonal Antibody

APCS (dezamizumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA001898MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    APCS（dezamizumab Biosimilar Antibody）重組單克隆抗體是一種針對人類APCS蛋白，其別名為9.5S alpha 1糖蛋白抗體、血清淀粉樣P成分抗體、PTX2抗體等，來源于重組人APCS蛋白，具有高度的人源種屬反應(yīng)性。 dezamizumab藥物主要針對與APCS蛋白相關(guān)的疾病機制展開探索。APCS作為pentraxin家族成員，在炎癥反應(yīng)、淀粉樣蛋白沉積及免疫調(diào)節(jié)中發(fā)揮關(guān)鍵作用，因此該抗體研發(fā)的藥物可能用于淀粉樣變性、自身免疫性疾病等的靶向治療。臨床前研究顯示，通過特異性結(jié)合APCS蛋白，該抗體研發(fā)的藥物可調(diào)控炎癥信號通路，減少病理性蛋白聚集，為相關(guān)疾病的治療提供新方向。目前，針對該其的臨床試驗主要集中于藥效驗證及安全性評估，旨在為后續(xù)適應(yīng)癥拓展奠定基礎(chǔ)。 APCS重組單克隆抗體是研究APCS蛋白功能的重要工具。借助其高特異性和親和力，精準(zhǔn)檢測APCS在細(xì)胞或組織中的表達(dá)定位及水平變化。在基礎(chǔ)研究中，該抗體有助于揭示APCS在免疫應(yīng)答、疾病發(fā)生發(fā)展中的分子機制，例如探索其在腫瘤微環(huán)境調(diào)控、神經(jīng)退行性疾病中的作用。此外，作為其研發(fā)的參照標(biāo)準(zhǔn)，其性能參數(shù)為同類藥物的質(zhì)量控制和一致性評價提供了科學(xué)依據(jù)，推動生物制藥領(lǐng)域的標(biāo)準(zhǔn)化研究。 綜上，APCS重組單克隆抗體兼具臨床轉(zhuǎn)化潛力與科研應(yīng)用價值，為APCS相關(guān)疾病的機制研究和治療策略開發(fā)提供了有力支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    9.5S alpha 1 glycoprotein antibody; 9.5S alpha-1-glycoprotein antibody; Amyloid P component serum antibody; APCS antibody; MGC88159 antibody; Pentaxin related antibody; Pentraxin 2 antibody; PTX 2 antibody; PTX2 antibody; SAMP_HUMAN antibody; SAP antibody; Serum Amyloid P antibody; Serum amyloid P component antibody; Serum amyloid P-component(1-203 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human APCS protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
  • 基因功能參考文獻(xiàn)：
    1. The findings suggest that the F57I mutation affects the aggregation process of lysozyme resulting in the formation of cytotoxic species and that SAP is able to prevent cell death in the F57I flies by preventing accumulation of toxic F57I structures. PMID: 27428539
    2. Data suggest that SAP (serum amyloid P-component) interacts with at least 33 proteins/ligands in plasma containing physiological calcium levels; these ligands can be categorized to include apolipoproteins, complement system proteins, coagulation proteins, and components that regulate proteolysis. PMID: 28098450
    3. Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects. PMID: 27754964
    4. SNPs in APCS were associated with late age at onset in familial amyloid polyneuropathy. PMID: 26286643
    5. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
    6. Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions. PMID: 25084341
    7. Compared to wildtype C57BL/6 mice, we find that in Apcs-/- "SAP knock-out" mice, bleomycin induces a more persistent inflammatory response and increased fibrosis. PMID: 24695531
    8. The effects of SAP and Xiapex (Collagenase Clostridium histolyticum) on fibrocytes derived from Dupuytren's disease, was evaluated. PMID: 24933153
    9. plasma protein serum amyloid P binds to FcgammaRI on monocytes to inhibit fibrocyte differentiation, and binds to FcgammaRIIa on neutrophils to reduce neutrophil adhesion. PMID: 25024390
    10. In the late phase post-myocardial infarct there is a coordinated decrease in immune response-inflammation proteins, except for SAP which showed an increase related to the specific activation of the classical complement pathway. PMID: 23992930
    11. 9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen gamma, thrombin, complement C3) were identified as a potential diagnostic pattern of Parkinson's disease. PMID: 23385359
    12. Human SAP binds phosphoethanolamine, while rabbits seem to have low levels of SAP that bind to a lesser extent. PMID: 23600950
    13. These results indicate that SAP functions as a host defense factor, similar to other peptidoglycan recognition proteins and nucleotide-binding oligomerization domain-like receptors. PMID: 23966633
    14. SAP may act as an effective receptor mimic to limit influenza A virus infection of airway epithelial cells. PMID: 23544079
    15. Persons who develop non-affective psychoses have lower levels of certain acute phase proteins, including SAP, at the time of birth. PMID: 23423137
    16. [review] On the basis of structure, serum amyloid P component is a prototype of the short pentraxin family. PMID: 23527487
    17. SAP has a new role in reducing the toxicity of early amyloidogenic aggregates in transthyretin amiloidosis. PMID: 23390551
    18. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation PMID: 22493081
    19. Low levels of serum amyloid P mark the brains of individuals who escape dementia despite the presence of beta amyloid plaques and tangles in Alzheimer's disease neuropathology. PMID: 22205573
    20. Studies indicate that pharmaceutical grade serum amyloid P component and C-reactive protein were isolated and purified. PMID: 22867744
    21. The START domain in GPBP is important for this interaction. SAP and GPBP form complexes in blood and partly colocalize in amyloid plaques from Alzheimer disease patients. PMID: 22396542
    22. Serum amyloid P level increased by approximately 5-fold in Parkinson's disease samples;a potential feasibility of plasma amyloid P as a marker to approach Parkinson's disease PMID: 21223953
    23. Under physiological conditions, phosphoethanolamine is bound with higher affinity by human SAP than by human CRP. PMID: 21360619
    24. TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. PMID: 21044893
    25. these data suggest that local production of serum amyloid P and c-reactive protein in the alzheimer disease brain does not substantially contribute to the CSF levels. PMID: 20930309
    26. Human SAP inhibits DNA-mediated innate immune activation in vitro and may limit innate and adaptive immune responses after DNA vaccination of transgenic mice. PMID: 21278351
    27. serum SAP levels may be an easy detected predictor for the healing of burn wounds PMID: 20932823
    28. Interaction between MBL and PTX3 led to communication between the lectin and classical complement pathways via recruitment of C1q, whereas SAP-enhanced complement activation occurs via a hitherto unknown mechanism PMID: 21106539
    29. SAP has an effect on macrophages in fibrotic lung disease PMID: 20300636
    30. Functional analysis demonstrated that SAP associated with HDL promotes SR-BI-dependent cholesterol efflux and lipid-free SAP enhances ABCA1-dependent cholesterol efflux PMID: 20189569
    31. A possible role of SAP in either host resistance or viral virulence was investigated during influenza infection in vivo. Influenza virus infection is not affected by serum amyloid P component.Human SAP binds much more avidly than mouse SAP to the virus. PMID: 11984001
    32. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. PMID: 12015594
    33. serum amyloid P component does not circulate in complex with C4-binding protein, fibronectin or any other major protein ligand PMID: 12100475
    34. structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose PMID: 12126626
    35. Serum amyloid p component binds to late apoptotic cells and is involved in the phagocytosis of these cells by human monocyte-derived macrophages. PMID: 12528126
    36. Serum amyloid P component binding to Shiga toxin 2 requires both a subunit and B pentamer. PMID: 14500533
    37. Purified SAP inhibits fibrocyte differentiation at levels similar to those found in plasma, while depleting SAP reduces the ability of plasma to inhibit fibrocyte differentiation. PMID: 14607961
    38. This protein, a non-fibrillar component, causes soluble fibrils to condense into localized fibrillar aggregates with a greatly enhanced local density of fibril entanglements. PMID: 15031287
    39. Genetic variation in APCS is associated with amyloid polyneuropathy PMID: 15649951
    40. Amyloid-associated SAP significantly increases fibrillar prion protein-related peptide-induced release of interleukin-6 and TNF-alpha from human microglia. PMID: 15837583
    41. Review discusses clinical significance of different levels of SAP, its role in induction or protection from autoimmunity, and the presence of specific SAP autoantibodies in different autoimmune diseases. PMID: 16380821
    42. the shared specificity as well as their shared capability to activate complement, suggest that IgM and the pentraxins CRP and SAP exert similar functions in the removal of apoptotic cells PMID: 16643876
    43. Monocytes bound biotinylated serum amyloid P component with avidity in a dose-dependent and saturable manner; speculated that binding of SAP by monocytes could be of physiological relevance at extravascular sites by influencing complement regulation PMID: 16784490
    44. Serum amyloid P (SAP) and C-reactive protein (CRP) may represent different facets of inflammation. The association of SAP with cardiovascular disease in these older adults further supports the role of innate immunity in atherosclerosis. PMID: 17138933
    45. No reduced circulating concentrations of serum amyloid P component (SAP) in patients with systemic sclerosis, nor any evidence of an association between SAP levels and the extent or severity of fibrosis were observed. PMID: 17530641
    46. SAP may modulate the inflammatory response to amyloid fibrils in atherosclerosis PMID: 17630380
    47. SAP was quantitated using PVDF affinity probes and MALDI-MS. PMID: 17676666
    48. The complex structure between human SAP and FcgammaRIIa reveals a diagonally bound receptor on each SAP pentamer with both D1 and D2 domains of the receptor contacting the ridge helices from two SAP subunits. PMID: 19011614
    49. Our data suggest that measurement of cerebrospinal fluid SAP levels can aid in the identification of incipient Alzheimer's disease among mild cognitive impairment patients PMID: 19052452
    50. Serum amyloid P binds to cells in the early stage of apoptosis, presumably via phosphatidylethanolamine exposed in flip-flopped membranes, suggesting a role for serum amyloid P in the clearance of these cells in vivo. PMID: 11441067

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  • 相關(guān)疾?。?/div>
    SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Pentraxin family
  • 組織特異性：
    Found in serum and urine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 584

    OMIM: 104770

    KEGG: hsa:325

    STRING: 9606.ENSP00000255040

    UniGene: Hs.507080



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