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  4. ACVR2B (Bimagrumab Biosimilar) Recombinant Monoclonal Antibody

ACVR2B (Bimagrumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA623829MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    ACVR2B（Bimagrumab Biosimilar Antibody）重組單克隆抗體是一種靶向激活素A受體IIB型（ACVR2B），其別名為Activin A receptor type IIB antibody、ActR IIB antibody、ACVR2B antibody等。該抗體以重組人ACVR2B蛋白制備而成，具有高度的種屬反應性，主要針對人類ACVR2B受體發(fā)揮作用。 Bimagrumab因其能夠特異性結合ACVR2B受體，阻斷激活素等配體的信號傳導，在肌肉減少癥、惡病質及相關代謝疾病領域展現(xiàn)出潛在應用價值。研究表明，ACVR2B信號通路的抑制可促進肌肉生長、減少脂肪堆積，改善患者的肌肉力量和身體功能。目前，針對該抗體研發(fā)的藥物的臨床試驗主要集中于評估其在慢性腎病、癌癥惡病質等疾病中的療效與安全性，旨在為肌肉流失相關疾病提供新的治療選擇。 ACVR2B重組單克隆抗體作為特異性工具，廣泛應用于ACVR2B受體功能研究、信號通路機制探索及相關疾病模型構建。通過實驗，可深入分析ACVR2B在細胞增殖、分化及代謝調節(jié)中的作用，為開發(fā)靶向ACVR2B的新型治療藥物提供理論依據和實驗基礎。其對人類ACVR2B的特異性結合能力，確保了實驗結果的準確性和可靠性，是生命科學研究領域的重要試劑。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Activin A receptor type IIB antibody; Activin receptor type 2B antibody; Activin receptor type IIB antibody; Activin receptor type-2B antibody; ActR IIB antibody; ACTR-IIB antibody; ActRIIB antibody; ACVR 2B antibody; ACVR2B antibody; AVR2B_HUMAN antibody; HTX4 antibody; MGC116908 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ACVR2B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
  • 基因功能參考文獻：
    1. the A allele of genetic variant rs2276541 in ACVR2B is associated with lean muscle mass PMID: 26848890
    2. ActR-IIB is expressed in male germ cells and Sertoli cells. PMID: 26289399
    3. We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19. PMID: 25051287
    4. miR-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs. PMID: 25203845
    5. Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain. PMID: 22296042
    6. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response. PMID: 22395277
    7. The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay. PMID: 22431721
    8. Mutations in Activin A Receptor Type IIB were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies. PMID: 21864452
    9. discussion of crystal structure of kinase domain of ActRIIB; structural analysis may be of help in developing selective inhibitors [REVIEW] PMID: 21353874
    10. Inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. PMID: 20466801
    11. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
    12. activin signaling via type II receptors requires a specific sequence for ALK4 binding PMID: 15123686
    13. These results indicate that haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength, although these data indicate sex-specific relationships. PMID: 17347381
    14. The high-resolution structure of human ActRIIB kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. PMID: 17893364

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  • 相關疾病：
    Heterotaxy, visceral, 4, autosomal (HTX4)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 數據庫鏈接：

    HGNC: 174

    OMIM: 602730

    KEGG: hsa:93

    STRING: 9606.ENSP00000340361

    UniGene: Hs.174273



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