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ACVR2A (LAE-102 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA001260MB1HU
  • 規(guī)格:
    ¥83486
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    ACVR2A(LAE-102 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途設(shè)計的生物制劑,通過基因工程技術(shù)在哺乳動物細胞中表達制備,具有高特異性和生物活性。該抗體靶向激活素受體2A(ACVR2A),這是一種跨膜絲氨酸/蘇氨酸激酶受體,在TGF-β超家族信號通路中發(fā)揮關(guān)鍵調(diào)控作用。ACVR2A參與細胞增殖、分化、凋亡及組織穩(wěn)態(tài)等多種生理過程,其異常表達與腫瘤發(fā)生、纖維化疾病及代謝紊亂等病理機制密切相關(guān)。 作為科研工具,ACVR2A重組單克隆抗體可用于多種實驗場景,包括,助力研究人員在分子水平解析ACVR2A的功能及相關(guān)信號通路。該抗體經(jīng)嚴格純化和活性驗證,確保低批次間差異與高批次穩(wěn)定性,適合長期實驗需求。此外,其高親和力特性使其能夠高效識別內(nèi)源性ACVR2A蛋白,為探索受體-配體相互作用、信號轉(zhuǎn)導機制及疾病模型構(gòu)建提供可靠支持。 在腫瘤研究領(lǐng)域,ACVR2A抗體可用于分析受體在腫瘤微環(huán)境中的表達模式,探討其對腫瘤細胞侵襲、轉(zhuǎn)移及免疫逃逸的影響;在纖維化疾病研究中,可助力揭示ACVR2A信號在組織纖維化進程中的調(diào)控作用;在干細胞研究中,有助于闡明其在細胞命運決定中的分子機制。通過特異性阻斷或激活ACVR2A信號,該抗體為深入研究相關(guān)疾病的發(fā)病機制及潛在治療靶點提供了重要實驗手段,推動生命科學基礎(chǔ)研究及轉(zhuǎn)化醫(yī)學領(lǐng)域的發(fā)展。
  • Uniprot No.:
  • 基因名:
  • 別名:
    LAE 102 research-grade biosimilar; LAE-102 research-grade biosimilar ;ACVR2A antibody; ACVR2 antibody; Activin receptor type-2A antibody; EC 2.7.11.30 antibody; Activin receptor type IIA antibody; ACTR-IIA antibody; ACTRIIA antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human ACVR2A protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能:
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
  • 基因功能參考文獻:
    1. Altered decidual ACVR2A expression impairs the ability of stromal cells to properly decidualise and regulate trophoblast function at the maternalfetal interface, which may result in abnormal placentation that can lead to poor pregnancy outcomes such as pre-eclampsia. PMID: 29203340
    2. Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2 in women with preeclampsia PMID: 29593124
    3. TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.( PMID: 27696331
    4. This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality. PMID: 27832070
    5. Data suggest ALK1 and ACVR2A/ACVR2B, acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling. PMID: 26677222
    6. Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. PMID: 26047946
    7. Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (as seen in pre-eclampsia). PMID: 25659497
    8. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors. PMID: 26086422
    9. The gene ACVR2A was associated with the more severe early onset preeclampsia. PMID: 25499008
    10. For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies. PMID: 23633461
    11. ACVR2A was identified as a subnetwork component in functional association network analysis. PMID: 23263486
    12. ACVR2A showed statistically significant differential dose-expression relationship. PMID: 22848350
    13. ACVR2A interaction with Nodal and ADMP regulates head development from the 'organizer', a restricted group of cells in the embryo. PMID: 22949641
    14. This is the first report on the function of miR-195 in human placental trophoblast cells which reveals an invasion-promoting effect of the small RNA via repressing ActRIIA. PMID: 22723898
    15. Activin type IIA receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain. PMID: 22296042
    16. Exonic selectivity for frameshift mutation within ACVR2 is specifically controlled by individual nucleotides flanking each coding ACVR2 microsatellite. PMID: 22001236
    17. Mutation in activin type II receptor is associated with colorectal cancer. PMID: 20197483
    18. crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor PMID: 12667445
    19. Activin type II receptor gene (ACTRII) is probably involved in both non-microsattelite unstable and microsattelite-unstable colorectal carcinogenesis, but more frequently in the latter subgroup. PMID: 14691305
    20. Data indicate that activin A and activin receptors IIA and IIB may be involved in the regulation of germ cell proliferation in the human ovary during the period leading up to primordial follicle formation. PMID: 14738881
    21. Mutations highly frequent in microsatellite unstable(MSI-H) colon cancers and cause loss of ACVR2, indicating biallelic gene nactivation. Loss of activin signaling through mutation of ACVR2 may have role in genesis of MSI-H colorectal cancer. PMID: 14988818
    22. demonstrates that truncating mutations of the ACVR2 gene result in a significant reduction in activin mediated cell signaling. Inactivation of ACVR2 is a common event in prostate cancer and may play an important role in the development of prostate cancer PMID: 16337854
    23. structure of the ternary complex representing the signaling competent complex of BMP-2 bound to the entire extracellular domains of both its type I receptor, BMPR-Ia, & its type II receptor, ActRII, at a resolution of 2.2 angstroms PMID: 16672363
    24. Activin is growth suppressive and enhances migration in colon cancer. PMID: 17258738
    25. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    26. Inhibin/activin BA subunit, follistatin, and activin receptor proteins and mRNAs are present in the human fetal palate. PMID: 18001154
    27. Populations with different ancestors (Iceland/Norway-Australia/New Zealand) demonstrate a common maternal pre-eclampsia susceptibility locus on chromosome 2q22-23, may suggests a general role of this locus, and possibly the ACVR2A gene, in pre-eclampsia. PMID: 18781190
    28. The -1 bp frameshift mutation rates of TGFBR2 and ACVR2 microsatellite sequences are dependent upon the human DNA Mismatch PMID: 18941508
    29. It remains unclear what role, if any, ACVR2A polymorphisms play in pre-eclampsia risk, at least in these Australian families. PMID: 19126782
    30. ActRII signaling is required for prostatic cancer cell and neuroblastoma cell viability, with ActRII mediating cell fate via the regulation of cell adhesion PMID: 19308291
    31. The four most frequently mutated genes in colorectal cancers with microsatellite instability were ACVR2 (92%), TAF1B (84%), ASTE1/HT001 (80%) and TGFBR2 (77%). PMID: 19503063

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  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 173

    OMIM: 102581

    KEGG: hsa:92

    STRING: 9606.ENSP00000241416

    UniGene: Hs.470174



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