日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Gap junction beta-1 protein (Gjb1)

Recombinant Mouse Gap junction beta-1 protein (Gjb1)

  • 中文名稱：
    小鼠Gjb1重組蛋白
  • 貨號：
    CSB-CF009451MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Gjb1
  • Uniprot No.：
  • 別名：
    Gjb1; Cxn-32; Gap junction beta-1 protein; Connexin-32; Cx32
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-283
  • 氨基酸序列
    MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC NSVCYDHFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEV KRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCEAFPCPNTVDCF VSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLS PEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能參考文獻(xiàn)：
    1. The results of this study indicated that the Leu89Pro substitution in the second transmembrane domain of CX32 disrupts the trafficking of the protein, inhibiting the assembly of CX32 gap junctions, which in turn may result in peripheral neuropathy. PMID: 27367520
    2. We show that the cell-surface and secreted isoforms of CSF-1 have opposing effects on macrophage activation and disease progression in a mouse model of connexin32-deficientconnexin32-deficient mice PMID: 26865613
    3. Blockade of endothelial Cx32 increased tissue factor expression induced by TNF-alpha stimulation and cell-cell interaction via ICAM1. Direct Cx32-mediated interaction modulates TF expression in ECs during vascular inflammation. PMID: 25171777
    4. These findings support a role for Cx32 in non-myelinating and regenerating populations of Schwann cells in normal axonal maintenance in re-myelination, and regeneration of peripheral nerve following injury PMID: 25447941
    5. These results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency. PMID: 23001129
    6. Cx32 therapy improves gap junctional conductance results in larger infarct size, and no antiarrhythmic efficacy. PMID: 22374989
    7. Data show that absence of connexin30 in knockout mice changes the expression patterns of connexin26 and connexin32 in glial cells and leptomeninges. PMID: 22098503
    8. Cx32 can functionally replace Cx26 in the mouse cochlea resulting in almost normal hearing PMID: 21813206
    9. Induction of Cxs 29 and 32 in the injury border suggests that altered Cxs may contribute to the propagation of injury-related and/or regeneration signals after acute brain injury. PMID: 20926974
    10. oligodendrocyte-astrocyte gap junction coupling in Cx32 or Cx47 knockout mice. In corpus callosum, oligodendrocytes appeared to be directly coupled to other oligodendrocytes. O:O coupling was more affected in mice lacking Cx32 than in mice lacking Cx47. PMID: 21396451
    11. Asn(175) of Cx32 is a critical residue for heterotypic docking and functional gap junction channel formation between the Cx32 and Cx26 hemichannels. PMID: 21478159
    12. These findings suggest that altered Cx32 expression, a loss of intercellular Cx32 and a gain of intracytoplasmic Cx32 in the form of punctate "dot", plays an important role in the formation of gastric adenocarcinomas. PMID: 21082351
    13. Cx32 protects ECs from inflammation by regulating cytokine expression and plays an important role in the maintenance of vascular function PMID: 21036166
    14. oligodendrocytes in white matter form a functional syncytium predominantly among each other dependent on Cx47 and Cx32 expression, while astrocytic connexins expression can promote the size of this network PMID: 20468052
    15. An age-related increase in the number of macrophages in demyelinating nerves of Cx32-deficient mice suggests involvement of macrophages might be common in genetically-determined demyelination. PMID: 11849753
    16. Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytes PMID: 11978007
    17. The direct calmodulin (CaM) role in chemical gating was tested with CaM mutants, and CaM-connexin 32 (Cx32) colocalization was demonstrated in the liver. PMID: 12064602
    18. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene. PMID: 12557153
    19. Expression profile of the Gjb1 in the developing mouse cochlea PMID: 12617848
    20. An increase in proliferating nestin+ and NG2+ oligodendrocyte progenitors in the subgranular zone, hilus, and polymorphonuclear layer of the dentate gyrus was noted in connexin32 deficient mice PMID: 12629180
    21. Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth PMID: 12805295
    22. Mice lacking either Cx47 or Cx32 are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss PMID: 12843301
    23. Comparative mapping of Y1 and Y5 receptor subtypes within cell bodies and nerve fibers in the brain. Together with physiological and electrophysiological studies, provides better understanding of NPY neural circuitries. PMID: 12900929
    24. This study used freeze-fracture replica immunogold labeling to detect Cx32 in ultrastructurally defined gap junctions in Schmidt-Lanterman incisures, as well as in a novel location, between the outer two layers of internodal myelin PMID: 15056698
    25. Cx32 is localized on the outer membrane of large myelin sheaths PMID: 15293232
    26. The hepatic response to endotoxin is markedly impaired in the absence of Cx32. PMID: 15336523
    27. Connexin32 acts as a lung tumor suppressor in a mouse model. Cx32-deficient lung tissue exhibited an increased proliferative index, and, after exposure to diethylnitrosamine, Cx32-deficient mice exhibited a significant increase in lung tumor incidence. PMID: 15492231
    28. Cx32 expression is in part related to induction of tight junctions through modulation of Mag-1 expression in an immortalized hepatic cell line. PMID: 15558322
    29. Selective permeability of Cx43 junctions is regulated through protein kinase C (PKC)-dependent phosphorylation at serine 368 (S368). PMID: 16709897
    30. Findings indicate Cx43alpha1 may have a novel function in mediating crosstalk with cell signaling pathways that regulate polarized cell movement essential for the directional migration of CNCs. PMID: 16914489
    31. Cx43 KO mice showed continued Sertoli cell proliferation and delayed maturation in adulthood, indicating that CX43 plays key roles in Sertoli cell development PMID: 17229929
    32. In conclusion, neurodevelopment of Shuffler/Cx43 cKO mice is abnormal, and the observed cellular phenotype may explain behavioral disturbances seen in these animals as well as in humans carrying Cx43 mutations. PMID: 17311295
    33. Results indicate that Cx32 in wild-type mice protects hematopoietic stem cell from chemical abrasion and leukemogenic impacts. PMID: 17463168
    34. Connexin32-immunofluorescent puncta were essentially absent in suprachiasmatic nucleus PMID: 17904757
    35. Homomeric interactions of Cx29 and Cx32 require other domains: the N-terminus, transmembrane domains, and extracellular loops. Substituting the intracellular loop and/or tail of Cx32 with those of Cx29 prevents Cx32 from forming gap junctions. PMID: 17972320
    36. The data suggests that ablation of Cx43 in the oocyte and its decrease in surrounding somatic cells, allows normal oogenesis, folliculogenesis, ovulation and early embryonic development but severely impairs implantation of the resulting blactocysts. PMID: 18005958
    37. Connexin 43 was decreased in testis of mutant mice with impaired spermatogenesis. PMID: 18162455
    38. analysis of the atomistic model of the Cx32 connexon PMID: 18648547
    39. Glial growth factor 2, an isoform of neuregulin 1, up-regulated Cx32 in both proliferating and non-proliferating Schwann cells PMID: 19218461
    40. Cx32, which negatively controls thyroid growth activated by thyrotropin via the cAMP pathway, would act as a positive effector of thyroid growth triggered by oncogenes acting through other signaling cascades. PMID: 19509066
    41. The effects of metabolic inhibition on the calcium metabolizing activity of mouse connexin 32 hemichannels in stably transfected HeLa cells is reported. PMID: 19587218

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Beta-type (group I) subfamily
  • 數(shù)據(jù)庫鏈接：


×
生命科學(xué)計(jì)算平臺(tái)