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  4. Recombinant Saccharomyces cerevisiae High mobility group protein 1 (HMO1)

Recombinant Saccharomyces cerevisiae High mobility group protein 1 (HMO1)

  • 中文名稱：
    Recombinant Saccharomyces cerevisiae High mobility group protein 1 (HMO1)
  • 品名簡(jiǎn)稱：
    Recombinant Saccharomyces cerevisiae HMO1 protein
  • 貨號(hào)：
    CSB-EP199576SVG
  • 說(shuō)明書(shū)：
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    HMO1
  • Uniprot No.：
  • 別名：
    High spontaneous mutagenesis protein 2
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長(zhǎng)度：
    Full Length
  • 來(lái)源：
    E.coli
  • 分子量：
    34.5 kDa
  • 表達(dá)區(qū)域：
    1-246aa
  • 氨基酸序列
    MTTDPSVKLKSAKDSLVSSLFELSKAANQTASSIVDFYNAIGDDEEEKIEAFTTLTESLQTLTSGVNHLHGISSELVNPIDDDKDAIIAAPVKAVRRKIERDPNAPKKPLTVFFAYSAYVRQELREDRQKAGLPPLSSTEITQEISKKWKELSDNEKEKWKQAYNVELENYQREKSKYLEAKKNGTLPPASLENGPTHAPVPIPFSLQHAAEPPVEKRPHDDDGSSEKKKKKKKKDKKKDKSNSSI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

相關(guān)產(chǎn)品

靶點(diǎn)詳情

  • 功能：
    DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.
  • 基因功能參考文獻(xiàn)：
    1. Persistent induction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO1 mRNA, but only in the presence of Tor1p. This down-regulation is accompanied by eviction of Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p. PMID: 28701348
    2. HMO1 appears to have evolved a unique linker histone-like function involving the ability to stabilize both conventional nucleosome arrays as well as DNA regions characterized by low nucleosome density or the presence of noncanonical nucleosomes. PMID: 27903656
    3. studied the genome-wide binding patterns of Nhp6, Hmo1 and the SWI/SNF complex, finding that most of gene promoters presenting high occupancy of this complex also display high enrichment of these HMG proteins. PMID: 28089519
    4. Hmo1p functions to control DNA end resection, thereby preventing error-prone A-EJ repair and directing repairs towards classical NHEJ. The very low efficiency of DSB repair in kuDeltahmo1Delta cells further suggests that excessive DNA resection is inhibitory for A-EJ. PMID: 28336179
    5. Both HMG boxes in Hmo1 are essential for DNA binding PMID: 25410521
    6. Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence. PMID: 25979266
    7. Hmo1's C-terminal tail, implicated in chromatin bending, facilitates the formation of catenations/hemicatenations and mediates the roles of Hmo1 in DNA damage tolerance pathway choice and sister chromatid junction formation. PMID: 24473148
    8. Aurhors propose that Hmo1 has acquired species-specific functions and shares with UBF1 and Schizosaccharomyces pombe-Hmo1 an ancestral function to stimulate rDNA transcription. PMID: 24021628
    9. The HMO1 promoter is regulated by TOR signaling through an HMO1- and Fhl1-dependent mechanism. PMID: 21924331
    10. Hmo1 plays a novel role in transcription by forming the 5'-boundary (instead of -1 nucleosome on many other promoters) for the pre-initiation complex assembly zone on a subset of ribosomal protein genes promoters. PMID: 21288884
    11. the combined activity of the Hmo 1 and the Ixr1 proteins provides efficient correction of both repair and replication errors. PMID: 20734765
    12. The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending PMID: 20402481
    13. HMO1 contains two functional DNA binding domains PMID: 15507436
    14. Taken together, our data suggest that interactions between box A and the C-terminal tail induce a conformation that is required for DNA bending. PMID: 16533046
    15. Hmo1 has a role in coordinating the transcription of rRNA and RP genes. PMID: 16612005
    16. Data show that Hmo1 is directly involved in coordinating rDNA transcription by Pol I and ribosomal protein gene expression by Pol II under the control of the TOR pathway. PMID: 17875934
    17. HMO1 may participate in start site selection of a subset of class II genes presumably via its interaction with TFIID. PMID: 18187511
    18. Data demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1. PMID: 18451108
    19. Data indicate that Top2 is dispensable for transcription and that Hmo1 and Top2 bind in the proximity of genes transcribed in S phase suppressing chromosome fragility at the mitosis-G1 transition. PMID: 19737516

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  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Note=Colocalizes with FOB1.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: sce:YDR174W

    STRING: 4932.YDR174W



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