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  4. Recombinant Mouse Glutathione peroxidase 3 (Gpx3) (U73S)

Recombinant Mouse Glutathione peroxidase 3 (Gpx3) (U73S)

  • 中文名稱：
    Recombinant Mouse Glutathione peroxidase 3 (Gpx3) (U73S)
  • 品名簡稱：
    Recombinant Mouse Gpx3 protein
  • 貨號(hào)：
    CSB-EP009868MO(M)
  • 說明書：
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    Plasma glutathione peroxidase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    29.8 kDa
  • 表達(dá)區(qū)域：
    25-226aa(U73S)
  • 氨基酸序列
    QEKSKTDCHGGMSGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVASYSGLTDQYLELNALQEELGPFGLVILGFPSNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTAELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPVMRWYHRTTVSNVKMDILSYMRRQAALSARGK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
  • 基因功能參考文獻(xiàn)：
    1. the antioxidant enzyme GPX3 localizes to lung extracellular matrix and is variably upregulated in interstitial lung diseases. PMID: 27435875
    2. These results suggest that GPx3 is an important factor for inhibition of Acetaminopheninduced hepatotoxicity both in vivo and in vitro. PMID: 28677736
    3. GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum. PMID: 27918237
    4. Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3) is not. PMID: 25068390
    5. GPx3 may have a possible role in modulating prostate carcinogenesis. PMID: 21374652
    6. Sepp1(UF) and small selenium-containing proteins are filtered by the glomerulus and taken up by PCT cells via megalin-mediated endocytosis, preventing loss of selenium in the urine and providing selenium for the synthesis of glutathione peroxidase-3 PMID: 24434121
    7. GPX3 may play a major role in reducing hydrogen peroxide during decidualization. PMID: 24631040
    8. an immunomodulatory role for GPX3 that limits the development of colitis-associated carcinoma. PMID: 23221387
    9. We applied X-ray fluorescence microscopy to image selenium in mammalian tissues and identified a highly localized pool of this trace element at the basement membrane of kidneys that was associated with GPx3 PMID: 21854231
    10. These results show that glutathione peroxidase 3 from the blood binds to basement membranes of specific epithelial cells and indicate that the cells modify their basement membranes to cause the binding. PMID: 21493731
    11. GPx-3 deficiency results in a prothrombotic state and vascular dysfunction that promotes platelet-dependent arterial thrombosis PMID: 21518981
    12. Inflammatory injury in the intestine elicits an increase in E-GPx in the plasma that is associated with an increase in E-GPx mRNA in the kidney. This implies that renal production of E-GPx may be sensitive to insults distal to the kidney. PMID: 11978890
    13. The expression of Gpx3 decreased at the aortic sinus in a murine model of high-fat diet-induced atherogenesis. PMID: 16508038
    14. GPX-3 may play a significant role in protecting cardiomyocytes from oxidative stress caused by hyperglycemia PMID: 16651743
    15. This is the first report that a particular isotype of the glutathione peroxidase family is regulated by TCDD at both mRNA and protein levels PMID: 16682824
    16. c-maf may be transcriptional regulator of GPx3 expression and modulate the antioxidative pathway in the kidney PMID: 16890189
    17. GPx3 expression was reduced selectively in the adipose tissue of several obese animal models as decreasing plasma GPx3 level. PMID: 18562625

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Glutathione peroxidase family
  • 組織特異性：
    Secreted in plasma.
  • 數(shù)據(jù)庫鏈接：


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