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  4. Recombinant Human Thrombospondin type-1 domain-containing protein 7A (THSD7A), partial

Recombinant Human Thrombospondin type-1 domain-containing protein 7A (THSD7A), partial

  • 中文名稱：
    Recombinant Human Thrombospondin type-1 domain-containing protein 7A (THSD7A), partial
  • 品名簡稱：
    Recombinant Human THSD7A protein, partial
  • 貨號：
    CSB-EP891984HU
  • 說明書：
  • 規(guī)格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    THSD7A
  • Uniprot No.：
  • 別名：
    THSD7A;KIAA0960
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    29.3 kDa
  • 表達區(qū)域：
    48-247aa
  • 氨基酸序列
    AAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in actin cytoskeleton rearrangement.; The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
  • 基因功能參考文獻：
    1. We propose a revised clinical workup flow for patients with MN that recommends assessment of kidney biopsy for PLA2R1 and THSD7A antigen expression, screening for circulating anti-podocytes antibodies, and assessment for secondary causes, especially cancer, in patients with THSD7A antibodies PMID: 29511687
    2. THSD7A-associated membranous nephropathy has a low prevalence in Chinese patients. PMID: 28801527
    3. Several risk alleles related to the PLA2R1 gene and within the HLA loci have been identified, whereas epitope spreading of PLA2R may predict treatment response. More recently, thrombospondin type 1 domain-containing 7A (THSD7A) antibodies have been discovered in primary membranous nephropathy . PMID: 28904948
    4. Anti-M-type phospholipase A2 receptor (anti-PLA2R) and anti-THSD7A (thrombospondin type-1 domain-containing 7A) were detected only in membranous neurophathy (MN) patient sera and not in controls. PMID: 27634909
    5. High THSD7A expression is associated with membranous nephropathy and cancer. PMID: 28035718
    6. This study provides novel data on the function of THSD7A in human placental cells, and extends knowledge of how miR-210 is involved in the development of the preeclampsia. PMID: 26796133
    7. THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. PMID: 26238973
    8. Data indicate that enhanced granular expression of phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) was detected in 9.1% and 52.7%, respectively, of the patients with idiopathic membranous nephropathy (MN). PMID: 26393352
    9. 15 of 154 patients with idiopathic membranous nephropathy had circulating autoantibodies to THSD7A but not to PLA2R1, a finding that suggests a distinct subgroup of patients with this condition. PMID: 25394321
    10. results suggest that Japanese subjects homozygous for the risk alleles of rs7605378 in FONG and rs12673629 in THSD7A have a significantly higher risk of vertebral fracture PMID: 23303384
    11. THSD7A is a membrane-associated N-glycoprotein with a soluble form. PMID: 22194972
    12. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20808825
    13. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    14. Observational study of gene-disease association. (HuGE Navigator) PMID: 20414141
    15. Thrombospondin type I domain containing 7A (THSD7A) mediates endothelial cell migration and tube formation. PMID: 20020485
    16. Variations may be important determinants of osteoporosis in Japanese women. PMID: 18488137
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 18488137

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  • 亞細胞定位：
    [Thrombospondin type-1 domain-containing protein 7A]: Cell membrane; Single-pass type I membrane protein. Cell projection.; [Thrombospondin type-1 domain-containing protein 7A, soluble form]: Secreted.
  • 組織特異性：
    Detected on kidney podocytes along the glomerular capillary wall (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22207

    OMIM: 612249

    KEGG: hsa:221981

    STRING: 9606.ENSP00000406482

    UniGene: Hs.120855



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