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  4. Recombinant Human Probable phospholipid-transporting ATPase VA (ATP10A), partial

Recombinant Human Probable phospholipid-transporting ATPase VA (ATP10A), partial

  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase VA(ATP10A) ,partial
  • 貨號：
    CSB-YP002310HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase VA(ATP10A) ,partial
  • 貨號：
    CSB-EP002310HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase VA(ATP10A) ,partial
  • 貨號：
    CSB-EP002310HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase VA(ATP10A) ,partial
  • 貨號：
    CSB-BP002310HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Probable phospholipid-transporting ATPase VA(ATP10A) ,partial
  • 貨號：
    CSB-MP002310HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ATP10A; ATP10C; ATPVA; ATPVC; KIAA0566Probable phospholipid-transporting ATPase VA; EC 7.6.2.1; ATPase class V type 10A; Aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).
  • 基因功能參考文獻(xiàn)：
    1. results suggest that enhanced PC flipping activity due to exogenous ATP10A expression alters the lipid composition at the plasma membrane PMID: 25947375
    2. has been proven that hypocaloric diets induce changes in the DNA methylation pattern in PBMCs (CpG18 of ATP10A and CpG 21 of WT1) and that some of these markers could be used as early indicators of response to metabolic effects of weight-loss programs PMID: 21209057
    3. ATP10A gene is imprinted, with preferential expression from the maternal allele in human brain. PMID: 11353404
    4. report the generation of the complete genomic structure PMID: 12105293
    5. In the analysis of a four-marker haplotype located in ATP10C, a statistically significant difference was observed in the frequency of one haplotype between male autism patients and controls PMID: 18186074
    6. monoallelic expression of human ATP10A is variable in the population and is influenced by both gender and common genetic variation PMID: 18726118

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  • 相關(guān)疾病：
    Angelman syndrome (AS)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 組織特異性：
    Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13542

    OMIM: 105830

    KEGG: hsa:57194

    STRING: 9606.ENSP00000349325

    UniGene: Hs.638517



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