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  4. Recombinant Human Homeobox protein Nkx-2.3 (NKX2-3)

Recombinant Human Homeobox protein Nkx-2.3 (NKX2-3)

  • 中文名稱：
    人NKX2-3重組蛋白
  • 貨號：
    CSB-YP848391HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NKX2-3重組蛋白
  • 貨號：
    CSB-EP848391HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NKX2-3重組蛋白
  • 貨號：
    CSB-EP848391HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NKX2-3重組蛋白
  • 貨號：
    CSB-BP848391HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NKX2-3重組蛋白
  • 貨號：
    CSB-MP848391HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NKX2-3
  • Uniprot No.：
  • 別名：
    NKX2-3; NKX23; NKX2CHomeobox protein Nkx-2.3; Homeobox protein NK-2 homolog C
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-364
  • 氨基酸序列
    MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG AACAQGTLQG IRAW
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription factor.
  • 基因功能參考文獻(xiàn)：
    1. Studies suggest oncogenic NK2 homeobox 3 homeobox protein (NKX2-3) in lymphomagenesis, and show a mouse model for studying the biology and therapy of human marginal-zone B-cell lymphomas. PMID: 27297662
    2. NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts PMID: 27036009
    3. The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD. PMID: 24473197
    4. NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1. PMID: 21968973
    5. A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients. PMID: 22377701
    6. The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay. PMID: 21803625
    7. the risk haplotype of NKX2.3 confers susceptibility to UC through increasing expression of NKX2.3 mRNA in the colonic mucosa. PMID: 21514341
    8. NKX2-3 may play an important role in inflammatory bowel disease pathogenesis by regulating endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PMID: 21637825
    9. Data suggest that NKX2-3 and IRGM are susceptibility loci for inflammatory bowel disease in Eastern European patients. PMID: 21049557
    10. Nkx2-3 may contribute to the pathogenesis of inflammatory bowel disease-associated colorectal cancer and sporadic colorectal cancer by regulating the Wnt signaling pathway. PMID: 20165982
    11. a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of inflammatory bowel disease, such as EDN1. PMID: 20188614
    12. Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis PMID: 18438405
    13. A positive association signal presumably common to different ethnic groups for rs10883365 was detected in the upstream region of NKX2-3. PMID: 18936107

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7836

    OMIM: 606727

    KEGG: hsa:159296

    STRING: 9606.ENSP00000342828

    UniGene: Hs.243272



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