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  4. TCL1A Recombinant Monoclonal Antibody

TCL1A Recombinant Monoclonal Antibody

  • 中文名稱：
    TCL1A Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA198357A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA198357A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing jurkat cells stained with CSB-RA198357A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1), TCL1A, TCL1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide from human TCL1A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9B8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
  • 基因功能參考文獻(xiàn)：
    1. Combination of T-cell lymphoma-1 protein (TCL1)-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing. PMID: 29449575
    2. Case Report: hematogones can express TCL-1 in patients with T-cell prolymphocytic leukemia after therapy. PMID: 28232160
    3. TCL1A is not only a useful biomarker for prognostic evaluation in stage II/III colorectal cancer patients. PMID: 28178623
    4. Our results suggest that intratumoral TCL1A+ B cells are important for controlling cervical cancer development. PMID: 26299617
    5. Our study suggests that TCL1 expression profile may have a role in the prediction of overall outcome in patient with MCL and call for prospective studies. PMID: 25688912
    6. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenstrom macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact. PMID: 26493619
    7. Suggest miR-181b as therapeutic target for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model. PMID: 26090867
    8. High TCL1A expression is associated with chronic lymphocytic leukemia. PMID: 25936528
    9. Polymorphic genetic variations of cytochrome P450 19A1 and T-cell leukemia 1A genes in the Tamil population PMID: 25481307
    10. Peptide-based TCL1-interphase mimics were potent in steric AKT antagonization. PMID: 25348018
    11. demonstrated that miR-3676 targets three consecutive 28-bp repeats within 3'UTR of TCL1 and showed that miR-3676 is a powerful inhibitor of TCL1 PMID: 25646413
    12. Case Report: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRgamma-TCL1A translocation] confirmed by FISH. PMID: 24966976
    13. Report frequent TCL1A rearrangements in T-cell prolymphocytic leukemia with cutaneous involvement. PMID: 25310835
    14. TCL1-Tg:p53(-/-) leukemia cells exhibit higher survival capacity and are more drug resistant than the leukemia cells from TCL1-Tg:p53wt mice PMID: 23608884
    15. TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q. PMID: 22875623
    16. SNPs near the 3' terminus of TCL1A were associated with aromatase inhibitors-dependent musculoskeletal pain. Estradiol induced SNP-dependent TCL1A expression. PMID: 22405131
    17. Data indicate that up-regulated transcription of TCL1A was observed in two cases. PMID: 22553924
    18. Our findings reveal a functional interaction between Tcl1 and Hsp70 and identify Tcl1 as a novel Hsp70 client protein PMID: 23160471
    19. Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
    20. These findings demonstrate that the microenvironment has a proactive role in the regulation of the known signaling enhancer and pro-survival molecule TCL1 in CLL. PMID: 22460735
    21. TCL1 is hyperexpressed in multiple B-cell lymphomas. PMID: 22645177
    22. 100% of dysgerminomas were positive for TCL1, but all immature teratomas were negative. PMID: 22448662
    23. genetic association studies in a Japanese population: Data suggest that a substantial number of patients with T-cell prolymphocytic leukemia exhibit abnormal expression of TCL1A probably due to rearrangement in region of TCL1 gene. PMID: 22189846
    24. CLL samples with high Tcl1 expression showed a decrease in DNA methylation compared with CLL samples with low Tcl1 expression PMID: 22308499
    25. Using primary chronic lymphocytic leukemia cells we have shown an inverse relationship between TCL1 and PTPROt expression. PMID: 22001392
    26. Data indicate an inverse correlation between miR-16-1, miR-181a, miR-181b, and level of expression of TCL-1 and BCL-2, which suggest that these miRNAs may implicate in negatively regulating target mRNA at transcriptional level. PMID: 21130495
    27. This study identified 4 single nucleotide polymorphisms related to TCL1A that, when present, were associated with musculoskeletal adverse effects to anastrozole or exemestane treatment in postmenopausal women with stage I to III breast cancer. PMID: 21172079
    28. TCL1 is a diagnostic marker for intratubular germ cell neoplasia and classic seminoma. PMID: 20553335
    29. TCL1 positivity was predominantly found in germinal center phenotype diffuse large B-cell lymphoma. PMID: 20382409
    30. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. PMID: 20357824
    31. Immunohistochemical evaluation of TCL1 expression may be useful for substantiating a diagnosis of unclassified type of intratubular germ cell neoplasia or seminoma. PMID: 20395523
    32. TCL1 mRNA expression may predict clinical outcome in CLL and that the IGHV3-21 subset, regardless of mutational status, displays high TCL1 expression. PMID: 19889012
    33. establish that the association between TCL1A and IkappaB is compatible with AKT binding to TCL1A, but incompatible with IkappaB binding to NF-kappaB PMID: 19668332
    34. An exposed hydrophobic patch composed of two discontinuous amino acid stretches has been identified near one end of the TCL1 beta-barrel that is required for TCL1-AKT binding association. PMID: 12009899
    35. Increased TCL1 expression correlates with PBC-ALL progression and loss of TEL expression. TCL1 expression is important for the maturation of precursor lymphocytes but not differentiated B or T cells. PMID: 12127395
    36. data demonstrate that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas PMID: 12381789
    37. oncogene transactivation by Sp1 PMID: 12421830
    38. results further support derivation of blastic tumors of skin from dendritic cells and demonstrate TCL1 proto-oncogene protein expression in this tumor PMID: 12576313
    39. altered expression in Burkitt lymphomas in the presence of Epstein-Barr virus PMID: 12672960
    40. Involved in the pathogenesis of mature leukemias and lymphomas: mature T-cell leukemia and chronic lymphocytic leukemia(review) PMID: 15325703
    41. Akt kinase activity can be inhibited by a peptide spanning the betaA strand of the proto-oncogene TCL1 PMID: 15459205
    42. Detailed mechanism for TCL1-augmented signaling helps explain the delayed occurrence of mature T cell expansions and leukemias despite tumorigenic TCL1 dysregulation that begins in early thymocytes. PMID: 16002684
    43. In EBV-negative diffuse large B-cell lymphoma and Burkitt lymphoma-derived cell lines infected in vitro with a recombinant EBV, high expression of EBNA2 inversely correlated with expression of germinal center-associated genes, BCL6 and TCL1. PMID: 17151114
    44. Expression levels of microRNA generally inversely correlated with Tcl1 expression in chronic lymphocytic leukemia. PMID: 17178851
    45. Biological action of the proto-oncogene TCL1 family and the development avenues for a suppressive drug specific for Akt, a core intracellular survival regulator.[REVIEW] PMID: 17360849
    46. TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. PMID: 17548807
    47. TCL1 expression in B-cell tumors parallels its regulation in non-neoplastic B cells and can be used diagnostically as an indicator of the differentiation stage of a given B-cell tumor. PMID: 17592280
    48. TCL1A deregulation may be caused by faulty gene silencing as a potential consequence of losses of 7q miRNAs in splenic marginal zone lymphoma. PMID: 17625607
    49. Lower TCL-1 levels were associated with improved complete remission rate and progression-free survival PMID: 17659340
    50. TCL1 inhibits activation-induced cell death in T cells by blocking PKCtheta and ERK activation, upon cellular activation PMID: 17846228

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  • 相關(guān)疾病：
    Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction.
  • 蛋白家族：
    TCL1 family
  • 組織特異性：
    Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11648

    OMIM: 186960

    KEGG: hsa:8115

    STRING: 9606.ENSP00000385036

    UniGene: Hs.2484



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