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EXOSC7 Recombinant Monoclonal Antibody

  • 中文名稱:
    EXOSC7 Recombinant Monoclonal Antibody
  • 貨號(hào):
    CSB-RA225279A0HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of Exosome component 7 expression in HepG2 cells using Exosome component 7 antibody. Green, isotype control; red, Exosome component 7.
    • Immunocytochemical staining of HepG2 cells with Exosome component 7 antibody. Nuclei were stained blue with DAPI; Exosome component 7 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
    • Immunohistochemistry was performed on paraffin-embedded human sigmoid colon carcinoma using exosome component 7 antibody. Antigen retrieval was done in sodium citrate buffer (pH 6.0). DAB was used for detection, with hematoxylin counterstaining. Images were acquired using a Nikon Ci-L Plus microscope (40× objective). Scale bar: 25 μm.
    • Western blotting analysis using exosome component 7 antibody. Total cell lysates (10 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with exosome component 7 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    EXOSC7
  • 別名:
    EXOSC7; Exosome Component 7; RRP42; P8; KIAA0116; EAP1; Ribosomal RNA-Processing Protein 42; Exosome Complex Component RRP42; HRrp42p; Rrp42p; Exosome Complex Exonuclease RRP42; HRRP42P; RRP42P
  • 反應(yīng)種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human EXOSC7 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號(hào):
    18A3
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, FC, ICC, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
    IHC 1:100-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
  • 基因功能參考文獻(xiàn):
    1. EXOSC7 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
    2. The association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p. PMID: 11812149
  • 亞細(xì)胞定位:
    Nucleus, nucleolus. Cytoplasm. Nucleus.
  • 蛋白家族:
    RNase PH family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28112

    OMIM: 606488

    KEGG: hsa:23016

    STRING: 9606.ENSP00000265564

    UniGene: Hs.719958



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