Recombinant Human UDP-galactose translocator (SLC35A2), partial

產(chǎn)品詳情

Uniprot No.：

P78381
基因名：

SLC35A2
別名：

SLC35A2; UGALT; UGT; UGTL; UDP-galactose translocator; Solute carrier family 35 member A2; UDP-galactose transporter; UDP-Gal-Tr; UGT
免疫原種屬：

Homo sapiens (Human)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.
基因功能參考文獻：
1. The short N-terminal region composed of 35 N-terminal amino-acid residues of UGT was crucial for galactosylation of N-glycans. PMID: 25451267
2. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). PMID: 25944901
3. De novo mutations in SLC35A2 encoding a UDP-galactose transporter cause early-onset epileptic encephalopathy. PMID: 24115232
4. The data further supports the hypothesis that UGT and NGT cooperate in the UDP-Gal delivery for glycosyltransferases located in the Golgi apparatus. PMID: 23583405
5. Mosaicism of the UDP-galactose transporter SLC35A2 causes a congenital disorder of glycosylation. PMID: 23561849
6. localization of the UDP-Gal transporter may depend on the presence of the partner splice variant PMID: 21918738
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相關疾病：

Congenital disorder of glycosylation 2M (CDG2M)
亞細胞定位：

Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Nucleotide-sugar transporter family, SLC35A subfamily
數(shù)據(jù)庫鏈接：

HGNC: 11022

OMIM: 300896

KEGG: hsa:7355

STRING: 9606.ENSP00000247138

UniGene: Hs.21899