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  4. SERPINB13 Antibody

SERPINB13 Antibody

  • 中文名稱：
    SERPINB13兔多克隆抗體
  • 貨號：
    CSB-PA021069GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SERPINB13
  • 別名：
    HaCaT UV repressible serpin antibody; HaCaT UV-repressible serpin antibody; Headpin antibody; HSHUR7SEQ antibody; HUR7 antibody; Hurpin antibody; MGC126870 antibody; Peptidase inhibitor 13 antibody; PI-13 antibody; PI13 antibody; Protease inhibitor 13 antibody; Proteinase inhibitor 13 antibody; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 13 antibody; Serpin B13 antibody; Serpin peptidase inhibitor clade B (ovalbumin) member 13 antibody; SERPINB13 antibody; SPB13_HUMAN antibody; UV B repressed sequence HUR 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SERPINB13
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in the proliferation or differentiation of keratinocytes.
  • 基因功能參考文獻：
    1. clade B serpins help to maintain homeostasis by inducing protective humoral immunity PMID: 22593614
    2. These data demonstrate that RUNX1 is an important regulator of SERPINB13 and cathepsin K activity. PMID: 21723253
    3. A novel member of the serine proteinase inhibitor (Serpin) gene family that was originally cloned from a keratinocyte cDNA library. It has specificity for inhibiting lysosomal cysteine proteinases. PMID: 12504904
    4. Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. PMID: 12809493
    5. hurpin is expressed in skin and has a possible role in inflammatory processes or the regulation of endogenous or pathogen-derived proteinase activity PMID: 15885077
    6. Down-regulation of SERPINB13 is associated with head and neck squamous cell carcinoma PMID: 16357159
    7. the expression of hurpin was confined mainly to the basal layer in normal skin samples, whereas hurpin was overexpressed and redistributed in diseased skin PMID: 16433682
    8. Downregulation of SERPINB13 protein expression in HNSCC is positively associated with poor clinical outcome. Therefore, SERPINB13 seems to act as an important protease inhibitor involved in the progression of HNSCC. PMID: 19569240

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 組織特異性：
    Skin specific.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8944

    OMIM: 604445

    KEGG: hsa:5275

    STRING: 9606.ENSP00000341584

    UniGene: Hs.241407



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