Immunofluorescent analysis of HepG2 cells using CSB-PA896873LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade.
基因功能參考文獻(xiàn):
The SBNO2 is component of the pathways that contribute to the downstream anti-inflammatory effects of IL-10. PMID: 18025162
蛋白家族:
SBNO family
組織特異性:
Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.