Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA887109LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA887109LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA887109LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors.
基因功能參考文獻:
Expression of the REEP1/REEP2 subfamily appears to be restricted to neuronal and neuronal-like exocytotic tissues, consistent with neuronally restricted symptoms of REEP1 genetic disorders. PMID: 24355597
We have identified mutations in REEP2 in two families with relatively pure, early-onset hereditary spastic paraplegia, one with autosomal-dominant and the other with autosomal-recessive transmission. PMID: 24388663
In mouse, Reep2 enhances sweet receptor function by a different mechanism than Reep1 uses to enhance olfactory receptor function. PMID: 20943918
相關(guān)疾?。?/div>
Spastic paraplegia 72 (SPG72)
亞細胞定位:
Membrane; Multi-pass membrane protein.
蛋白家族:
DP1 family
組織特異性:
Detected in brain, heart and skeletal muscle, and at low levels in placenta, kidney and pancreas. Expressed in circumvallate papillae.