PSMC6 Antibody

產(chǎn)品詳情

Uniprot No.：

P62333
基因名：

PSMC6
別名：

26S protease regulatory subunit 10B antibody; 26S protease regulatory subunit S10B antibody; 26S proteasome AAA-ATPase subunit RPT4 antibody; CADP44 antibody; P44 antibody; Proteasome 26S subunit ATPase 6 antibody; Proteasome subunit p42 antibody; PRS10_HUMAN antibody; PSMC6 antibody; Rpt4 antibody; SUG2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human PSMC6.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
基因功能參考文獻(xiàn)：
1. Evidence of a sex-specific association of PSMC6 genetic variants with subtypes of juvenile idiopathic arthritis. PMID: 24875235
2. Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium. PMID: 25801217
3. N protein of SARS Coronavirus interacts with the host cell proteasome subunit p42. PMID: 20478047
亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

AAA ATPase family
數(shù)據(jù)庫鏈接：

HGNC: 9553

OMIM: 602708

KEGG: hsa:5706

STRING: 9606.ENSP00000401802

UniGene: Hs.156171