PIGM Antibody

說(shuō)明書(shū)

產(chǎn)品詳情

Uniprot No.：

Q9H3S5
基因名：

PIGM
別名：

PIGM antibody; GPI mannosyltransferase 1 antibody; EC 2.4.1.- antibody; GPI mannosyltransferase I antibody; GPI-MT-I antibody; Phosphatidylinositol-glycan biosynthesis class M protein antibody; PIG-M antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human PIGM
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
基因功能參考文獻(xiàn)：
1. B cells but not red cells are glycosylphosphatidylinositol deficient in PIGM-associated inherited glycosylphosphatidylinositol deficiency, caused by a core promoter mutation that abrogates Sp1 binding. PMID: 25293775
2. Studies indicate that mutations in PGM1 by exome sequencing cause hypoglycemia and liver abnormalities. PMID: 23329837
3. Mutation substantially reduces transcription of PIGM and blocks mannosylation of glycosylphosphatidylinositol(GPI), leading to partial but severe deficiency of GPI. PMID: 16767100
相關(guān)疾?。?/div>
Glycosylphosphatidylinositol deficiency (GPID)
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

PIGM family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 18858

OMIM: 610273

KEGG: hsa:93183

STRING: 9606.ENSP00000357069

UniGene: Hs.552810