NUP133 Antibody

說(shuō)明書(shū)

產(chǎn)品詳情

Uniprot No.：

Q8WUM0
基因名：

NUP133
別名：

133 kDa nucleoporin antibody; FLJ10814 antibody; hNUP 133 antibody; hNUP133 antibody; MGC21133 antibody; NU133_HUMAN antibody; Nuclear pore complex protein Nup133 antibody; Nucleoporin 133kDa antibody; Nucleoporin NUP133 antibody; NUP 133 antibody; NUP133 antibody; OTTHUMP00000061095 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human NUP133
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in poly(A)+ RNA transport. Involved in nephrogenesis.
基因功能參考文獻(xiàn)：
1. human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed beta-propeller. PMID: 15557116
2. When complexed with NUP107, this complex will give the first insights into the protein-protein interactions within a core module of the nuclear pore complex. PMID: 17768364
3. The significant topological differences between Nup107 and Nup133 suggest that helical nucleoporin domains of the nuclear pore complex scaffold fall in different classes and fulfill largely nonredundant functions. PMID: 18570875
4. Data present crystal structures of yNup170(979-1502) and hNup107(658-925) x hNup133(517-1156), and conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor. PMID: 19674973
亞細(xì)胞定位：

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore.
蛋白家族：

Nucleoporin Nup133 family
組織特異性：

Widely expressed in fetal and adult tissues. Expressed in the brain and kidney.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 18016

OMIM: 607613

KEGG: hsa:55746

STRING: 9606.ENSP00000261396

UniGene: Hs.12457