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  4. METTL14 Antibody

METTL14 Antibody

  • 中文名稱：
    METTL14兔多克隆抗體
  • 貨號(hào)：
    CSB-PA884519LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate
      All lanes: METTL14 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 kDa
      Observed band size: 53 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) METTL14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    KIAA1627 antibody; MET14_HUMAN antibody; Methyltransferase like 14 antibody; Methyltransferase-like protein 14 antibody; METTL14 antibody; N6-adenosine-methyltransferase subunit METTL14 antibody; OTTHUMP00000219837 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，METTL14 Antibody (CSB-PA884519LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于METTL14 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA884519LB01HU METTL14 Antibody, HRP conjugated ELISA
    FITC CSB-PA884519LC01HU METTL14 Antibody, FITC conjugated
    Biotin CSB-PA884519LD01HU METTL14 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.
  • 基因功能參考文獻(xiàn)：
    1. methyltransferase-like protein 14 in a complex with METTL3 mediates nuclear RNA methylation PMID: 24316715
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    MT-A70-like family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29330

    OMIM: 616504

    KEGG: hsa:57721

    STRING: 9606.ENSP00000373474

    UniGene: Hs.596872



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