KRT2 Antibody

產(chǎn)品詳情

Uniprot No.：

P35908
基因名：

KRT2
別名：

KRT2 antibody; KRT2A antibody; KRT2E antibody; Keratin antibody; type II cytoskeletal 2 epidermal antibody; Cytokeratin-2e antibody; CK-2e antibody; Epithelial keratin-2e antibody; Keratin-2 epidermis antibody; Keratin-2e antibody; K2e antibody; Type-II keratin Kb2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Fusion protein of Human KRT2
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin.
基因功能參考文獻(xiàn)：
1. Report genetic/clinical spectrum of KRT2 mutations in keratinopathic ichthyosis. PMID: 26581228
2. We describe two children with superficial epidermolytic ichthyosis confirmed by genetic testing, including one with a novel mutation. PMID: 22612346
3. influence of keratinocyte activation, proliferation, and keratinization on K2e expression in samples of cutaneous and oral lesions (keratin K2e) PMID: 12598329
4. novel H1 domain mutation in a family with icthyosis bullosa Siemens PMID: 17408392
相關(guān)疾?。?/div>
Ichthyosis bullosa of Siemens (IBS)
蛋白家族：

Intermediate filament family
組織特異性：

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expressi
數(shù)據(jù)庫鏈接：

HGNC: 6439

OMIM: 146800

KEGG: hsa:3849

STRING: 9606.ENSP00000310861

UniGene: Hs.707