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  4. GNA14 Antibody

GNA14 Antibody

  • 中文名稱：
    GNA14兔多克隆抗體
  • 貨號：
    CSB-PA080042
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AU023208 antibody; g alpha 14 antibody; G alpha-14 antibody; G protein alpha subunit 14 antibody; G protein subunit alpha 14 antibody; G-protein subunit alpha-14 antibody; gna14 antibody; GNA14_HUMAN antibody; Guanine nucleotide binding protein (G protein) alpha 14 antibody; Guanine nucleotide binding protein 14 antibody; Guanine nucleotide binding protein alpha 14 subunit antibody; Guanine nucleotide binding protein subunit alpha 14 antibody; Guanine nucleotide-binding protein subunit alpha-14 antibody; MGC105546 antibody; OTTHUMP00000021515 antibody; Tieg3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Gα 14.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
  • 基因功能參考文獻(xiàn)：
    1. The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b-stimulated Rho A GTPase-mediated serum response factor activation. PMID: 26823487
    2. findings identify GNA14 mutations as a cause of childhood vascular tumors, offer insight into mechanisms of oncogenic transformation by mutations affecting Gaq family members, and identify potential targets for therapeutic intervention PMID: 27476652
    3. Study suggests that the previously identified PLCbeta-interacting residues are insufficient to ensure productive interaction of Galpha14 with PLCbeta, while an intact N-terminal half of Galpha14 is apparently required for PLCbeta interaction. PMID: 26377666
    4. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. PMID: 23975421
    5. TPR1 is required for Galpha14 to stimulate Ras-dependent signaling pathways, but not for the propagation of signals along Ras-independent pathways. PMID: 22711498
    6. activation of the IKK/NFkappaB signaling cascade by SSTR2 requires a complicated network consisting of Galpha(14), protein kinase C, CamkII, ERK, and c-Src PMID: 16115892
    7. G14alpha and G16alpha are palmitoylated at distinct polycysteine sequences, and that the adjacent polybasic domain is not required for Galpha palmitoylation but is important for localization and functional activity of heterotrimeric G proteins PMID: 17620339
    8. The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses. PMID: 19687291

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  • 蛋白家族：
    G-alpha family, G(q) subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4382

    OMIM: 604397

    KEGG: hsa:9630

    STRING: 9606.ENSP00000365807

    UniGene: Hs.657795



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