FCHO1 Antibody, Biotin conjugated

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) FCHO1 Polyclonal antibody
Uniprot No.：

O14526
基因名：

FCHO1
別名：

FCHO1 antibody; KIAA0290F-BAR domain only protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human F-BAR domain only protein 1 protein (45-180AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
基因功能參考文獻(xiàn)：
1. Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. PMID: 27237791
2. The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2. PMID: 25303365
3. show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub PMID: 22484487
4. study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation PMID: 20448150
5. Involved in clathrin-coated vesicle formation. PMID: 17617719
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亞細(xì)胞定位：

Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
蛋白家族：

FCHO family
數(shù)據(jù)庫鏈接：

HGNC: 29002

OMIM: 613437

KEGG: hsa:23149

STRING: 9606.ENSP00000252771

UniGene: Hs.96485